Apex- Chemo agents

Question 1

Match each chemo agent with its unique side effect:
Cisplatin, Bleomycin, Doxorubicin

Pulmonary toxicity, renal toxicity, cardiac toxicity

Answer 1

Cisplatin + Renal toxicity
Bleomycin + Pulmonary toxicity
Doxorubicin + Cardiac toxicity

(x = cross my heart and hoope to die)

Question 2

Key Side effect of:
Cisplatin (2)

Answer 2

nephrotoxicity and acoustic nerve injury

Question 3

Key Side effect of:
Vincristine and vinblastine

Answer 3

peripheral neuropathy

Question 4

Key Side effect of:
Bleomycin

Answer 4

pulm fibrosis

*keep FiO2 < 30%

Question 5

Key Side effect of:
Doxorubicin

Answer 5

cardiotoxicity

*Doxy, X, cross my heart and hope to die

Question 6

Key Side effect of:
5-flurouracil

Answer 6

Bone marrow supression

Question 7

Key Side effect of:
Methotrexate

Answer 7

Bone marrow supression

Question 8

Which to chemo agents cause bone marrow supression

Answer 8

methotrexate and 5-flurouracil

Question 9

which 2 chemo agents cause peripheral neuropathy

Answer 9

vincristine and vinblastine

Question 10

which chemo agent is linked to cardiotoxicity

Answer 10

doxorubicin

Question 11

which chemo agent is linked to renal toxicity

Answer 11

cisplatin

Question 12

which chemo agent is linked to acoustic nerve injury

Answer 12

cisplastin

Question 13

Descibe chemo man

Answer 13

Question 14

Label whether the chemo agent is an alkalating agent, tubulin-binding drug, antitumor antibiotic, or antimetabolite:

Cisplatin

Answer 14

Alkalating agent

acoustin nerve injury and kidneys

Question 15

Label whether the chemo agent is an alkalating agent, tubulin-binding drug, antitumor antibiotic, or antimetabolite:

Vincristine and vinblastine

Answer 15

Tubulin-binding drugs

peripheral neuropathy

Question 16

Label whether the chemo agent is an alkalating agent, tubulin-binding drug, antitumor antibiotic, or antimetabolite:

Bleomycin

Answer 16

auntitumor antibotic

+ doxorubicin

Question 17

Label whether the chemo agent is an alkalating agent, tubulin-binding drug, antitumor antibiotic, or antimetabolite:

doxoruicin

Answer 17

antitumor antibiotic

+ bleomycin

Question 18

Label whether the chemo agent is an alkalating agent, tubulin-binding drug, antitumor antibiotic, or antimetabolite:

5-flurouracil

Answer 18

antimetabolitie

bone marrow supression

Question 19

Most chemotherapeutic agents cause what 2 things

what is the exception

Answer 19

bone marrow supression and thrombocytopenia

Bleomycin

Question 20

Just remember, think about the chemo agent they are on - will it alter the PK/PD of your anesthetic agents if the agent affects the heart, kidneys, or liver?

Answer 20

just a thought lol

Question 21

4 key thoughts when you have someone on chemo

Answer 21

1- labs, risk for bleeding - most cause bone marrow supression and thrombocytopenia
2- lytes- could be volume depleted if isisues with N/V (hgb may be falsely elevated if this is the case)
3- get a good look at their mucous membranes and ask them about it- may have to avoid OPA/NPA/ LMA/ Eso temp probe if +mucositis
4- what agent are they are - if it affects heart, liver , kidneys - the PK/PD profile of your agents might be altered

Question 22

What is tamoxifen

s/e

risk

Answer 22

selective estrogen receptor modulator

-tumors that do not express estorgen receptors are not responsive to tamoxifen

hot flashes

increased risk of endometrial cancer