apetite regulation Flashcards

1
Q

define appetite

A

the desire to eat food

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2
Q

define hunger

A

need of eating

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3
Q

define satiety

A

the feeling of fullness

disappearance of appetite after a meal

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4
Q

whats an underweight BMI

A

less than 18.5

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4
Q

how to calculate BMI

A

weight (kg) / height (m2)

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5
Q

whats a normal BMI

A

18.5 - 24.9

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6
Q

whats an overweight BMI

A

25.0 - 29.9

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7
Q

whats an obese BMI

A

30.0 - 39.9

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8
Q

whats a morbidly obese BMI

A

more than 40

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9
Q

risks of obesity

A
  • Type II diabetes
  • Hypertension
  • Coronary artery disease
  • Stroke
  • Osteoarthritis
  • Obstructive sleep apnoea
  • Carcinoma
    • Breast
      -Endometrium
      -Prostate
      -Colon
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10
Q

what factors determine obesity

A
  • what regulates weight and appetite?
  • why do most people keep a constant weight?
  • why are people getting fatter?
  • what can we do about it?
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11
Q

what does weight regulation depend on

A

environment + genes-> maintenance (homeostasis) system -> normal fat mass

negative feedback

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12
Q

why do we eat

A
  • Internal physiological drive to eat
  • Feeling that prompts thought of food and motivates food consumption
  • External physiological drive to eat
  • Sometimes even in the absence of hunger (e.g. buffet)
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13
Q

where is the hunger centre in the hypothalamus

A

lateral hypothaalus

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14
Q

where is the satiety centre in the hypothalamus

A

ventromedial hypothalamic nucleus

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15
Q

what factors control apetite

A
  • psychological factors
  • cultural factors
  • neural afferents
  • gut peptdes
  • metabolites
  • hormones
16
Q

what does leptin do

A

switches off appetite and is immunostimulatory

17
Q

what happens to blood levels after a meal

A

they increase

18
Q

what happens to blood levels after fasting

A

they decrease

19
Q

describe satiety of different nutrients

A

Highly refined sugar – quick and short satiety

Low glycaemic index foods – better

High protein – prolonged satiety

High fat – stimulate and entice people to eat more

20
Q

describe peptide YY

A

36 amino acids
Structurally similar to NPY
Binds NPY receptors
Secreted by neuroendocrine cells in ileum, pancreas and colon in response to food
Inhibits gastric motility
Reduces appetite

21
Q

describe cholecystokinin CCK

A

1973 – administration – reduced feeding in rodents
Receptors in pyloric sphincter
- Delays gastric emptying
- Gall bladder contraction
- Insulin release
And via vagus – satiety

22
Q

describe ghrelin

A

28 amino acids
acyl side chain
expressed in stomach

23
Q

what does ghrelin do

A

stimulates release of growth hormone

stimulates appetite

24
Q

what allows understanding of underlying pathways

A

Animal and human models

25
Q

is monogenic obesity common

A

no its rare

26
Q
A