APA Hematology Flashcards
In a patient with anemia where the MCH high at 105, MCHC low at 29, and a ferritin that is normal, what disorder is suspected indicating which test should be performed?
Thalassemia minor and hemoglobin electrophoresis
What tests can help to differential Folate Deficiency from B12 deficiency?
Homocystine and methylmalonic acid (MMA). Both are elevated in B12 deficiency and only homocystine in Folate Deficiency.
What test should be performed to diagnose pernicious anemia?
Parietal antibody test (antiparietal antibody) or intrinsic factor antibody (Anti-IF)
When treating a vitamin deficient anemic patient with presumed normal bone marrow, when would you expect to see an elevation in Hct/Hgb and when would you expect it to return to normal?
Increased in 1-2 weeks, normal 4-6 weeks.
What is the primary differentiating symptom between folate and B12 deficiency anemias?
Neurological impairment (gait, balance, mentation)
A patient with MCV of 76, low hct/hgb and rbc-the next step is to order TICB, Ferritin and Serium iron. If the ferritin and iron levels are low- which form of anemia is diagnosed
IDA
In anemia patient with MCV >100, what studies should be ordered?
Folate & B12 levels
CAGE tool helps to screen for what condition?
Alcohol abuse
Reticulocyte count decreases with what types of anemia?
Hypoproliferative disorders such as Nutritional deficiencies and bone marrow diseases
Reticulocyte count increases with?
Hemolytic anemia and sickle cell crisis
What does MCV determine?
Size of cell: microcytic (less than 80), normocytic (80-100) and macrocytic (>100)
What are two key differentiators in IDA?
Low ferritin and high TIBC
When differentiation thalassemia from IDA- what is one key finding?
In thalassemia, the TIBC will be normal and iron will be normal/high
MCV and MCH high, what kind of anemia is it?
Macrocytic, usually B12 or folate deficiency
Elevated neutrophils usually indicates what type of infection?
Bacterial