AP patterning

Question 1

what is a hox gene

Answer 1

homeotic gene. controls the development of the body plan. its coding sequence contains homeodomains for DNA binding. these genes give unique identity to the body segments along the AP axis. expressed in a collinear fashion

Question 2

collinearity

Answer 2

Hox gene expression is correlated with its position on the chromosome. the 3’ gene is expressed first. and anteriorly.

Question 3

what happens when you move the gene closer to the telomere

Answer 3

it starts to express earlier

Question 4

how do you achieve ectopic expression of the hox gene

Answer 4

place it closer to a gene with a strong enhancer sequence. it will share the other genes endogenous expression

Question 5

what and where is the RA gradient

Answer 5

high to low from anterior to posterior spinal cord and from hindbrain to forebrain.