Aortic dissection Flashcards
How common is aortic dissection in comparison to abdominal aortic aneurysm rupture?
3x as common (but still rare)
What is the pathophysiology of aortic dissection?
- tear in the tunica intima of the wall of the aorta
What are 3 possibilities as to how blood enters the tunica media of the aorta in aortic dissection?
- atherosclerotic ulcer leading to intimal tear
- Disruption of vasa vasorum causing intramural haematoma
- De novo intimal tear
What are 5 possible things that can occur following aortic dissection (i.e. blood flow into the tunica media)?
- Extension up or down
- Rupture
- Vessel branch occlusion
- Aortic regurgitation
- Pericardial effusion/ tamponade
What are 7 conditions associated with aortic dissection?
- Hypertension
- Trauma
- Bicuspid aortic valve
- Collagens: Marfan’s syndrome, Ehlers-Danlos syndrome
- Turner’s and Noonan’s syndrome
- Pregnancy
- Syphilis
What is the most important risk factor for aortic dissection?
hypertension
What are 5 clinical features of aortic dissection?
- Chest pain: typically severe, radiates through to back and ‘tearing’ in nature
- Pulse deficit: weak or absent carotid, brachial, or femoral
- Variation (>20 mmHg) in systolic BP between the arms
- Aortic regurgitation (early diastolic decrescendo murmur, eponymous clinical signs)
- Hypertension
What is the nature of the chest pain of aortic dissection?
- severe
- typically ripping or tearing in nature
- occurs suddenly and maximal at onset
- retrosternal or interscapular
- migrating, may go down the back
(but pain not always present)
How can the location of pain in aortic dissection suggest the part of the affected aorta?
retrosternal chest pain: anterior dissection
interscapular pain: descending aorta
What are 3 possible features of aortic dissection which may occur due to the involvement of specific branching arteries?
- Coronary arteries: angina
- Spinal arteries: paraplegia/paraesthesias
- Distal aorta: limb ischaemia
What should you remember about when to consider a diagnosis of aortic dissection, due to the frequency of atypical presentations of this condition?
- consider aortic dissection if there is a combination of chest/ back pain and new or evolving neurological deficits
What may ECG show in aortic dissection? 4 possibilities
- majority have no or non-specific ECG changes
- in minority of patients, ST segment elevation may be seen in inferior leads (right coronary artery dissection)
- Pericarditis changes
- Electrical alternans (tamponade)
What are 2 types of classification for aortic dissection?
- Stanford classification
- DeBakey classification
What are the 2 types of aortic dissection according to the Stanford classification?
- Type A: ascending aorta
- Type B: descending aorta, distal to left subclavian origin
What are the relative proportions of cases of Type A vs Type B aortic dissections (Stanford classification)?
- type A: 2/3
- type B: 1/3