Aortic dissection Flashcards

1
Q

How common is aortic dissection in comparison to abdominal aortic aneurysm rupture?

A

3x as common (but still rare)

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2
Q

What is the pathophysiology of aortic dissection?

A
  • tear in the tunica intima of the wall of the aorta
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3
Q

What are 3 possibilities as to how blood enters the tunica media of the aorta in aortic dissection?

A
  1. atherosclerotic ulcer leading to intimal tear
  2. Disruption of vasa vasorum causing intramural haematoma
  3. De novo intimal tear
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4
Q

What are 5 possible things that can occur following aortic dissection (i.e. blood flow into the tunica media)?

A
  1. Extension up or down
  2. Rupture
  3. Vessel branch occlusion
  4. Aortic regurgitation
  5. Pericardial effusion/ tamponade
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5
Q

What are 7 conditions associated with aortic dissection?

A
  1. Hypertension
  2. Trauma
  3. Bicuspid aortic valve
  4. Collagens: Marfan’s syndrome, Ehlers-Danlos syndrome
  5. Turner’s and Noonan’s syndrome
  6. Pregnancy
  7. Syphilis
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6
Q

What is the most important risk factor for aortic dissection?

A

hypertension

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7
Q

What are 5 clinical features of aortic dissection?

A
  1. Chest pain: typically severe, radiates through to back and ‘tearing’ in nature
  2. Pulse deficit: weak or absent carotid, brachial, or femoral
  3. Variation (>20 mmHg) in systolic BP between the arms
  4. Aortic regurgitation (early diastolic decrescendo murmur, eponymous clinical signs)
  5. Hypertension
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8
Q

What is the nature of the chest pain of aortic dissection?

A
  • severe
  • typically ripping or tearing in nature
  • occurs suddenly and maximal at onset
  • retrosternal or interscapular
  • migrating, may go down the back

(but pain not always present)

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9
Q

How can the location of pain in aortic dissection suggest the part of the affected aorta?

A

retrosternal chest pain: anterior dissection

interscapular pain: descending aorta

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10
Q

What are 3 possible features of aortic dissection which may occur due to the involvement of specific branching arteries?

A
  1. Coronary arteries: angina
  2. Spinal arteries: paraplegia/paraesthesias
  3. Distal aorta: limb ischaemia
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11
Q

What should you remember about when to consider a diagnosis of aortic dissection, due to the frequency of atypical presentations of this condition?

A
  • consider aortic dissection if there is a combination of chest/ back pain and new or evolving neurological deficits
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12
Q

What may ECG show in aortic dissection? 4 possibilities

A
  1. majority have no or non-specific ECG changes
  2. in minority of patients, ST segment elevation may be seen in inferior leads (right coronary artery dissection)
  3. Pericarditis changes
  4. Electrical alternans (tamponade)
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13
Q

What are 2 types of classification for aortic dissection?

A
  1. Stanford classification
  2. DeBakey classification
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14
Q

What are the 2 types of aortic dissection according to the Stanford classification?

A
  1. Type A: ascending aorta
  2. Type B: descending aorta, distal to left subclavian origin
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15
Q

What are the relative proportions of cases of Type A vs Type B aortic dissections (Stanford classification)?

A
  • type A: 2/3
  • type B: 1/3
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16
Q

What are the 3 types of aortic dissection according to the DeBakey classification?

A
  1. Type I: originates in ascending aorta, propagates to at least the aortic arch and possibly beyond it distally
  2. Type II: originates in and is confined to the ascending aorta
  3. Type III: originates in descending aorta, rarely extends proximally but will extend distally
17
Q

What should you do if a patient with suspected aortic dissection is hypo (rather than hyper-) tensive?

A

ensure not due to upper limb discrepancy caused by an occluded vessel - check BP in arm with best radial pulse

18
Q

What is a key bedside test to perform in suspected aortic dissection?

A

ECG

19
Q

What are 5 key blood tests to perform in suspected aortic dissection?

A
  1. FBC: leukocytosis likely
  2. Creatine Kinase: elevates with renal artery involvement
  3. Troponin - can cause myocardial ischaemia
  4. D-dimer: if negative dissection very unlikely, not sufficient to rule out
  5. Cross-match
20
Q

What are 5 types of imaging that can be performed in suspected aortic dissection?

A
  1. CXR
  2. Echocardiography: Transthoracic or Traonoesophageal (TOE)
  3. Helical CT/ CT angiography
  4. Aortography
  5. MRI/MRA
21
Q

What are 8 possible findings on a CXR for aortic dissection?

A
  1. normal in 11-16%
  2. widened mediastinum (56-63%)
  3. abnormal aortic contour (48%)
  4. aortic knuckle double calcium sign >5mm (14%)
  5. pleural effusion (L>R)
  6. Tracheal shift
  7. Left apical cap
  8. Deviated NGT
22
Q

What type of echocardiography is more sensitive and specific for aortic dissection?

A

transoesophageal

23
Q

What are 4 disadvantages of transoesophageal echocardiography for imaging aortic dissection?

A
  1. Operator-dependent
  2. Need sedation
  3. Less available
  4. Upper ascending aorta and arch not well visualised
24
Q

When is it useful to perform echo for suspected aortic dissection?

A

unstable patients who are too risky to take to CT scanner, and in ICU/perioperatively

25
Q

Which imaging method is the method of choice for aortic dissection?

A

CT angiography of chest, abdomen and pelvis

26
Q

What is the key finding on CT angiography suggesting aortic dissection?

A

false lumen

27
Q

What was the previous gold standard imaging for aortic dissection (replaced now by MRI/CT/echo)?

A

aortography

28
Q

What are the pros vs cons of MRI/MRA to diagnose aortic dissection?

A

excellent sensitivity and specificity but low availability

29
Q

What are the 3 emergency priorities in aortic dissection?

A
  1. control BP
  2. control bleeding
  3. fluid resuscitation
30
Q

What are 8 aspects of the immediate management of aortic dissection?

A
  1. give oxygen
  2. wide bore IV access (Swan sheath)
  3. invasive monitoring
  4. warn blood bank (cross match 6 units + need for other products)
  5. correct coagulopathy
  6. contorl HR and BP (aim for HR 60-80 an BP 100-120)
  7. IV beta blocker (propranolol, esmolol or labetalol) + vasodilators (e.g. GTN, labetalol, SNP)
  8. call cardiothoracic surgeon
31
Q

What are the 2 types of IV drugs you should give as part of the immediate management of aortic dissection and in what order?

A
  1. IV beta blocker: propranolol, esmolol, labetalol
  2. Vasodilators: GTN, labetalol, SNP

start beta blocker first to avoid increased aortic wall stress from reflex tachycardia

32
Q

What are 4 indications for surgery for aortic dissection?

A
  1. Persistent pain
  2. Type A (Stanford)
  3. Branch occlusion
  4. Leak
  5. Continued extension despite optimal medical management
33
Q

What must be achieved while awaiting surgical intervention for Type A aortic dissection?

A

blood pressure should be controlled to target systolic of 100-120 mmHg

34
Q

What is the management of Type B aortic dissection (Stanford)?

A

conservative management; bed rest, reduce BP with IV labetalol to prevent progression

35
Q

What are 6 possible complications of aortic dissection?

A
  1. aortic rupture
  2. aortic regurgitation
  3. acute myocardial infarction
  4. cardiac tamponade
  5. end-organ ischaemia (brain, limbs, spine, renal, gut, liver)
  6. death
36
Q

What type of management might be possible for type B aortic dissection in the future?

A

endovascular repair