Anxiolytics Flashcards
1
Q
Nonbenzodiazepine Anxiolytics
A
Buspirone
2
Q
Benzodiazepines: Short 1/2 life
A
Triazolam Oxazepam Temazepam Alprazolam (Xanax) Lorazepam Estazolam
3
Q
Benzodiazepines: Long 1/2 Life
A
Clonazepam
Chlordiazepoxide (librium)
Diazepam (Valium)
4
Q
Benzodiazepines: Other
A
Flumazenil
5
Q
Barbituates
A
Pentobarbitol
Amobarbitol
6
Q
Benzodiazepines that do not need first pass metabolism
A
Lorazepam
Oxazepam
Temazepam
Skip phase 1
treat alcoholics with lorazepam or oxazepam because it is easier on their liver
7
Q
buspirone
A
General Anxiety Disorder
Non-benzodiazepine anxiolytic
None of the negative side-effects seen in Benzos
Not effective if patient has been exposed to Benzos in the past
8
Q
Triazolam
A
Short 1/2 life Benzodiazepine (positive allosteric modulator of GABA-A receptor, increases flow of Cl- when GABA binds) Anxiolytic Sedative/hypnotic muscle relaxant anticonvulsant addictive Shortest onset
9
Q
Oxazepam
A
Short 1/2 life Benzodiazepine (positive allosteric modulator of GABA-A receptor, increases flow of Cl- when GABA binds) Anxiolytic Sedative/hypnotic muscle relaxant anticonvulsant addictive No first pass metabolism
10
Q
Temazepam
A
Short 1/2 life Benzodiazepine (positive allosteric modulator of GABA-A receptor, increases flow of Cl- when GABA binds) Anxiolytic Sedative/hypnotic muscle relaxant anticonvulsant addictive Very powerful No first pass metabolism
11
Q
Alprazolam (Xanax)
A
Short 1/2 life Benzodiazepine (positive allosteric modulator of GABA-A receptor, increases flow of Cl- when GABA binds) Anxiolytic Sedative/hypnotic muscle relaxant anticonvulsant addictive Very powerful
12
Q
Lorazepam
A
Short 1/2 life Benzodiazepine (positive allosteric modulator of GABA-A receptor, increases flow of Cl- when GABA binds) Anxiolytic Sedative/hypnotic muscle relaxant anticonvulsant addictive No First pass metabolism
13
Q
Estazolam
A
Short 1/2 life Benzodiazepine (positive allosteric modulator of GABA-A receptor, increases flow of Cl- when GABA binds) Anxiolytic Sedative/hypnotic muscle relaxant anticonvulsant addictive
14
Q
Clonazepam
A
Long 1/2 life Benzodiazepine (positive allosteric modulator of GABA-A receptor, increases flow of Cl- when GABA binds) unique 7-membered hetero-ring structure Anxiolytic Sedative/hypnotic muscle relaxant anticonvulsant addictive
15
Q
Chlordiazepoxide (librium)
A
Long 1/2 life Benzodiazepine (positive allosteric modulator of GABA-A receptor, increases flow of Cl- when GABA binds) unique 7-membered hetero-ring structure Anxiolytic Sedative/hypnotic muscle relaxant anticonvulsant addictive Fast acting (30-60 min)
