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Behavioral Science > Anti-Psychotics > Flashcards

Anti-Psychotics Flashcards

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0
Q

Typical Mid Potency Anti-Psycotics

A

Perphenazine

Molindone

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1
Q

Typical Low Potency Anti-Psychotics

A

Chlorpromazine

Thioridazine

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2
Q

Typical High Potency Anti-Psychotics

A

Haloperidol
Fluphenazine
Trifluoperazine
Thiothixene

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3
Q

Typical Low Potency Side Effect Profile

A 
Anticholinergic: increased temperature, decreased sweating, dry mouth, constipation, urinary retention, cognitive deficits, decreased seizure threshold, prolonged QT interval, blurred vision, closed angle glaucoma
Anti-alpha 1: orthostatic hypotension
Antihistaminic: sedation, weight gain
Tardive Dyskinesia
Neuroleptic Malignant syndrome
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4
Q

Typical High Potency Side Effect Profile

A 
Extra pyramidal symptoms (EPS): acute dystonia, akathisia, parkinsonism, 
Tardive Dyskinesia
NMS
Hyperprolactinemia
Treat EPS with anticholinergics
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5
Q

Chlorpromazine

A

Typical AP: blocks D2 receptor
Low potency
Most sedation AP, retinal pigmentation

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6
Q

Thioridazine

A

Typical AP: blocks D2 receptor
Low potency
Worst QT prolongation, retinal pigmentation

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7
Q

Perphenazine

A

Typical AP

Mid potency

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8
Q

Molindone

A

Typical AP: blocks D2 receptor
Mid potency
Only typical AP that doesn’t cause weight gain

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9
Q

Haloperidol

A

Typical AP: blocks D2 receptor
High potency
Most common AP in emergency setting

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10
Q

Fluphenazine

A

Typical AP: blocks D2 receptor

High potency

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11
Q

Trifluoperazine

A

Typical AP: blocks D2 receptor

High potency

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12
Q

Thiothixene

A

Typical AP: blocks D2 receptor

High potency

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13
Q

Typical Anti-Psychotics

A

1st generation
TD, NMS
Block D2 receptor

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14
Q

Atypical Low Potency Anti-Psychotics

A

Clozapine

Quetiapine

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15
Q

Atypical Anti-Psychotics

A 
2nd generation
Metabolic syndrome
Block a variety of receptors (less D2 activity)
1st line of treatment (except Clozapine)
Increased risk of stroke
16
Q

Atypical Mid Potency Anti-Psychotics

A

Olanzapine

Ziprazidone

17
Q

Atypical High Potency Anti-Psychotics

A 
Risperidone
Aripiprazole (Abilify)
18
Q

*Clozapine

A 
Atypical AP
Low potency
Many receptors: D2/3/4; 5HT1/2/3; M1; Alpha-1; H1
Most efficient AP
LAST RESORT
Worst side effects: metabolic syndrome, weight gain, sedation, orthostatic hypotension, AGRANULOCYTOSIS (blood tests every week for 6 months, 2 weeks forever), anticholinergic, antihistaminic, anti alpha-1, prolonged QT, myocarditis
Hyper salivation  
Short half life
19
Q

Quetiapine

A

Atypical AP
Low potency
Weight gain and moderate metabolic risk, less anticholinergic than clozapine
Cataracts in animals

20
Q

Ziprazidone

A

Atypical AP
Mid to low potency
No weight gain, LEAST RISK OF METABOLIC SYNDROME, low risk of QT prolongation
Sedation

21
Q

*Olanzapine

A

Atypical AP
Mid to high potency
Similar to clozapine molecularly
Significant weight gain, metabolic risk, increased liver enzymes, hypertriglyceridemia, bad lipid profile, decreased HDL, no agranulocytosis

22
Q

Risperidone

A

Atypical AP
High potency
High affinity for 5HT2 and D2
Most typical of atypical APs: EPS, TD, Hyperprolactinemia

23
Q

Aripiprazole (Abilify)

A 
Atypical AP
High potency
D2, 5HT2, Partial D1 agonist
No weight gain, increased risk of akathisia (treat with beta blocker)
Activator, so only give in the morning
24
Q

Anti-Cholinergics for psychotic disorders

A

Benzatropine/Atropine

Diphenhydramine (Benadryl)

25
Q

Benzatropine/Atropine

A

Psychotic disorders and Alzheimer’s disease
Anticholinergic
Treat EPS but not TD

26
Q

Diphenhydramine (Benadryl)

A

Psychotic disorders, insomnia, anxiety disorders
Anticholinergic, antihistamine
Treat EPS, not TD
Sedative

27
Q

Cholinergics

A

Betachenol

29
Q

Betachenol

A

Cholinergic
Stimulates M1 receptor (CNS)
Reduces anticholinergic effects

Behavioral Science (9 decks)

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