Anxiety Disorders Flashcards
What’s included in anxiety disorders?
Panic Disorder, Generalized Anxiety Disorder, & Social Anxiety Disorder
Family and twin studies show anxiety has a genetic component in which disorder?
All of them (i.e., Panic Disorder, Generalized Anxiety Disorder, & Social Anxiety Disorder)
What does the Brain Derived Neurotrophic Factor (BDNF) do?
Regulated neuronal survival and differentiates during development and plays a role in ltp and memory.
Tell me a little more about Brain Derived Neurotrophic Factor (BDNF)
Associated with anxiety and depression
The allele of Brain Derived Neurotrophic Factor (BDNF) (VAL66Met) on chromosome 11 is responsible for what?
impairing extinction of a conditioned fear memory in humans and mice.
The Brain Derived Neurotrophic Factor (BDNF) allele results in atypical activity where?
vmPFC - amygdala circuitry
What happens during extinction of the Brain Derived Neurotrophic Factor (BDNF) allele on chormosome 11?
Decreased activity in the vmPFC.
Anxiety FMRI shows increased activity where?
Amygdala, cingulate, prefrontal & insular cortex
PET scans of those w/ panic attack in scanner shows…
decreased actvitiy in R orbitofrontal and anterior cingulate, anddddd aMYGDALA
What happened in the fMRI where ppl with Social Anxiety viewed pics of facial expressions of anger, disgust, and fear?
increased activity in amygdala
What might the increase activity in the amygdala and viewing expression of anger, disgust, and fear imply?
Positive correlation of amygdala activity and severity of anxiety sxs.
Those undiagnosed w/ high anxiety showed activation where?
amygdala and insular
What happens in activation of prefrontal cortex in healthy controls?
It inhibits the amygdala, but not in people with anxiety disorder.
