Anxiety Disorders Flashcards

1
Q

What is the definition of anxiety?

A
  • A feeling of unease, such as worry or fear, that can be mild or severe.
  • A diagnosis is made if feeling of anxiety occurs all the time.
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2
Q

What is a panic disorder?

A
  • Unexpected panic attacks that may not be restricted to a specific situation or stimuli
  • Charachterised by intense and abrupt feeling of fear or discomfort.
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3
Q

What are symptoms of anxiety disorders?

A
  • Palpitation or inc HR
  • Sweating
  • Trembling
  • Sensations or shortness of breath
  • Feelings of choking
  • Chest pain
  • Nausea or abdominal stress
  • Feelings of dizziness/light-headed
  • Chills or hot flushes
  • Tingling or lack of sensation in extremitites
  • Depersonalisation or derealisation
  • Fear of losing control or going mad
  • Fear of imminent death
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4
Q

What is OCD?

A
  • Combination of obsessive thoughts and compulsive activity
  • Obsession: Unwanted/unpleasant thoughts that cause anxiety e.g. being burgled.
  • Person tries to supress these thoughts through compulsions.
  • Compulsion:Repititve behaviour a person undertakes to relieve the unpleasant feeling
  • Diagnosis: Both the obsessions and compulsions must be time consuming and result in sig impact on day-day function.
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5
Q

What is PTSD?

A
  • Develops after experiencing threatening or horrific event/series of events
  • Charachterised by:
    1.Re-experiencing traumatic event
    2.Avoidance of thoughts and mem attributed to the event
    3.Persistent perceptions of heightened threat
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6
Q

What are some additional symptoms of PTSD?

A
  • Insomnia
  • Nightmares
  • Flashbacks
  • Isolation
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7
Q

What is a specific phobia?

A
  • An intense fear of something that, in reality, is of little or no actual danger.
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8
Q

What is social phobia/social anxiety disorder?

A
  • Fear of social or performanc situations resulting from thoughts of neg judgement, embarassment or humiliation.
  • Person ‘tolerates’ with dread or avoids situation.
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9
Q

What is Generalised anxiety disorder?

A
  • Excessive, uncontrollable worry about every day things, such as:
    1. Job
    2. Finances
    3. Health
    4. Family
    5. Chores
    6. Car repairs
    7. Late for things
  • The intenity, duration and freq of the worry are disproportionate to the issue.
  • May also be present with physical symptoms e.g. palpitations, sweating, trembling etc.
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10
Q

Why is the prefrontal cortex important?

A
  • Intellectual function AND emotional behaviour(suppresses aggro behaviou)
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11
Q

Why is the amygdala important?

A
  • Involved in processing emotional behaviour?
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12
Q

Why are the amygdala and prefrontal cortex linked?

A
  • A decrease in the connectivity between them leads to GAD.
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13
Q

How much do genes and the environment contribute to GAD?

A
  • Genes-30-50%
  • Environment-50-70%

Environment is more important.

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14
Q

How does GABA affect GAD?

A
  • Dysregulation of GABA inhibitory neurotransmission
  • GABAa receptor downregulation observed in GAD patients
  • Symptoms of GAD are effectively treated with GABAa agonsits
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15
Q

How does 5-HT affect GAD?

A
  • SSRIs have efficacy for GAD
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16
Q

How does Corticotrophin-releasing factor affect GAD?

A
  • No effect in clinical trial
17
Q

How do neuropeptides affect GAD?

A
  • GAD patients are hypersensitive to cholecystokinin (CCK) agonists
  • Unsuccessful trials investigating CCK-antagonists.
18
Q

What is the mechanism of GAD and neuroendocrine?

A
  • Cortisol is a stress hormone
  • Adrenaline and Noradrenaline fight or flight
  • Neg feedback loop stops this chain(HPA) (see below)
    1. Hypothalamus, Anterior pituitary, Adrenal cortex->cortisol.
  • In GAD and depression this neg feedback loop that leads to cortisol is compromised and therefore more cortisol is produced.
19
Q

What are the considerations during an anxiety assessment?

A
  • Mental health history
  • Environmental stressors
  • Medical and drug history
  • Degree of distress and func impairment
  • Risk of suicide
20
Q

What are non-pharmacological methods of treatment?

A
  • Self-help
  • Meditation and relaxation techniques
  • Excercise
  • Lifestyle changes
21
Q

How do you manage GAD?

A

Interventions:
* Autonomic symptoms:
1. B-adrenoreceptors antagonists (propranolol)

      1. Reduces autonomic effect
    1. Do not withdraw abruptly to provent rebound effects
  • Anxiety symptoms:
    1. Psychological interventions
    1. Offer SSRIs- sertraline as first option
    1. Do not offer benzodiazepine except for short term use during a crisis
22
Q

What are Benzodiazepines used for?

A
  • Muscle relaxation
  • Insomnia
  • Pre-medication
  • Epilepsy
  • Alcohol withdrawal
  • Anxiety
23
Q

How do benzodiazepines work?

A
  • BDZ occupy site on GABAa receptor
  • BDZ binding->conformational change which allows GABA to bind
  • GABA binding->conformational change in GABAa receptor chloride channel
  • Greater flow of Cl- ions into the neurone
  • Hyperpolarisation=Inhibition