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Farmacologia talleres > Antivirico > Flashcards

Antivirico Flashcards

1
Q

Idoxuridina

Mecanismo de accion

A

-inhiben de forma selectiva la replicacion
-Analogo de la timidina
-Inhibe la ADN poly
=Aciclodir

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2
Q

Idoxuridina

Farmacocinetica

A

via topica. Profarmaco que se activa al ser metabolizado por las celulas infectadas.

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3
Q

Idoxuridina

Reacciones adversas

A
  • Irritacion local del ojo.
  • Dolor, purrito, edema palpebral
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4
Q

Idoxuridina

Espectro de accion

A
  • Herpès simple
  • Coxvirus
  • Anemovirus
  • viduela
  • solo frente a DNA virus
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5
Q

Idoxuridina

Applicationes terapeutica

A

Infecciones oculares y viruela. Queratoconjuntivitis en gatos. Tambien se utiliza como antineoplasica.

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6
Q

Aciclodir

Mecanismo de accion

A
  • inhiben de forma selectiva la replicacion
  • Analogo de la timidina
  • Inhibe la ADN poly
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7
Q

Aciclodir

Farmacinetica

A

Via topica y occular

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8
Q

Aciclodir

Reacciones adversas

A
  • Dolor occular
  • Edema palpebral
  • Purrito
  • Teratojeno y mutageno
  • Fotofobia y occlucion del conducto lagrimal
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9
Q

Aciclodir

Expectro de accion / Applicaciones adversas.

A

-Virus de herpes simple

Queratoconjuntivitis

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10
Q

Trifluridina

Mecanismo de accion

A
  • Inhibe timidina sintase (replication)
  • Analogo de la timidina
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11
Q

Trifluridina

Farmacocinetica

A

Via topica, oral e intravenosa

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12
Q

Trifluridina

Reacciones adversas

A
  • via topica oftalmoca quemadura y escator
  • via topica quemadura, purrito, eritema
  • IV nefrotoxicidad, neurotoxicidad.
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13
Q

Trifluridina

Espectro de accion

A
  • Virus de herpes simple
  • VVZ : Virus Varicel zoster
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14
Q

Trifluridina

Applicaciones terapeutica

A

Tratamiento y profilaxis de manifestaciones sistémicas y locales : exantemas, heridas, ulceras…

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15
Q

Interferon

Mecanismo de accion

A

Actividad antivirica, antiproliferativa y inmunoduladora.
Union receptores de la celula => sintesis de proteinas => inhibe la replicacion de RNA y DNA

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16
Q

Interferon

Farmacinetica

A

Via IM y subcutanea

17
Q

Interferon

Reacciones adversas

A
  • Disminuye la hematopoyesis
  • Fiebre
  • Alteraciones SNC
  • Hipotension
  • Teratogeno
18
Q

Interferon

Espectro de accion

A

(RNA virus)

  • influenzavirus
  • papillomavirus
  • Herpes virus
  • Retrovirus
  • paramixovirus
  • ortomixovirus
  • rabdovirus
  • togavirus
19
Q

Interferon

Resistencias

A

Adenovirus resistentes
Parvovirus (perros)
FELN/FIV (gatos)

20
Q

Interferon

Applicaciones terapeuticas

A
  • Infecciones
  • Antineoplasico(inmunomodulador)
21
Q

Amantadina

Mecanismo de accion

A

Actividad antivirica y antiparkinsaniano.
Inhibitor de proteina M2 (Decapsidacion viral)
Bloqueo descapsidacion virica. Inhibicion sintesis del ensamblaje
Interfiere en las primeras etapas replicacion DNA. (Virostatico)

22
Q

Amantadina

Farmacocinetica

A

Via Oral

23
Q

Amantadina

Reacciones adversas

A
  • Alteraciones SNC
  • Dificultad para concentrarse
  • Convulsiones
  • Neurotoxico
  • Anticolonergicos
  • Teratogeno
24
Q

Amantadina

Espectro de accion

A
  • *-Influenza A (gripe)**
  • Mixovirus
  • Togavirus
  • Paramixovirus
25
Q

Amantadina

Resistancia

A

Cepas resistantes, mutaciones de proteina M2

26
Q

Amantadina

Applicaciones térapeutica

A

-Influenza

27
Q

Zidovudina

Mecanismo de accion

A

Inhibition de transcriptasa inversa => Bloqueo sintesis DNA proviral

28
Q

Zidovudina

Farmacocinetica

A

Via oral
Biotransformacion hépatica

29
Q

Zidovudina

Reacciones adversas

A
  • Alteraciones hematologicas (anemias y granulocitopenia)
  • Nauseas y vomitos
  • Fiebre
  • Cefaleas
  • Miajas = dolor muscular
  • transtorno mieloprolefrativo
30
Q

Zidovudina

Espectro de accion

A
  • Retrovirus (FELV)
  • Lentivirus (VIF)
31
Q

Zidovudina

Resistencia

A

Mutaciones puntuales en el gen de la transcriptasa inversa

32
Q

Zidovudina

Applicationes terapeutica

A

-Lentevirus en gatos

33
Q

Nefrotoxicidad :

Hepatoxicidad :

Neurotoxicidad :

Teratogeno :

A

Nefrotoxicidad :

  • Aciclovir

Hepatoxicidad :

  • Aciclovir

Neurotoxicidad :

  • Aciclovir
  • Amantidina

Teratogeno :

  • Trifluridina
  • Interferon
  • Amantina

Farmacologia talleres (7 decks)

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