Antivirals - Hepatitis

Question 1

IFN MOA

Answer 1

Cytokines released from virus infected cells and activate other cells

Question 2

Interleukins role with IFN?

Answer 2

Interleukins up-regulate IFN synthesis in infected cells

Question 3

IFN-Alpha treats

Answer 3

Hepatitis B and V
Hairy cell leukemia
Malignant melanoma
Kaposi sarcoma
Condyloma accuminata
Renal cell carcinoma

Question 4

IFN-alpha adverse effects?

Answer 4

Flu-like syndrome
Tinnitus, retinopathy
Myelosuppression
Drug induced lupus

Question 5

IFN-Beta treats

Answer 5

Multiple sclerosis

Question 6

IFN-Gamma treats

Answer 6

Chronic granulomatous disease

Question 7

What is important to determine before starting Hep C treatment?

Answer 7

HCV genotype

Need to assess liver fibrosis

Question 8

Ribavirin MOA

Answer 8

Guanosine nucleoside analogue and inhibits RNA production

Question 9

Ribavirin adverse effect?

Answer 9

Dose dependent Hemolytic anemia

Teratogenic

Question 10

Sofosbuvir MOA

Answer 10

Nucleoside analogue that inhibits NS5B RNA production

Question 11

Simeprevir MOA

Answer 11

Inhibits NS34A protease

Question 12

Simeprevir adverse effects

Answer 12

CYP45 inhibitor

Photosensitivity and Rash