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Sketchy Pharm- Anti-viral > Antiviral - HIV > Flashcards

Antiviral - HIV Flashcards

1
Q

NRTI MOA

A

Competitive inhibition of reverse transcriptase by incorporating itself into DNA and cause premature chain termination

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2
Q

NRTI adverse effect?

A

Lactic acidosis

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3
Q

NRTI suffix

A

-dine

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4
Q

Lamivudine adverse

A

Peripheral neuropathy

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5
Q

Lamivudine treament

A

Hepatitis B infection

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6
Q

Tenofovir

A

Nucleotide analogue, does not need phosphorylation and treats Hep B

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7
Q

Zidovudine

A

Nucleoside analogue used during pregnancy to reduce vertical transmission

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8
Q

Zidovudine adverse

A

Myelosuppression
Granulocytopenia
Lipodystrophy

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9
Q

Staviduine adverse

A

Nucleoside analogue that can cause peripheral neuropathy

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10
Q

Didanosine adverse

A

Can cause dose dependent pancreatitis

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11
Q

Abacavir adverse

A

Hypersensitivity reaction (type 4) associated with HLA-B57

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12
Q

Emtricitabine adverse

A

Hyperpigmentation of palms and soles

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13
Q

Do nucleotide or nucleoside analogues need to be phosphorylated?

A

Nucleoside

These end with the suffix -dine

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14
Q

NNRTIs

A

Non-nucleoside reverse transcriptase inhibitors

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15
Q

NNRTI MOA

A

Do not need to be phosphorylated to bind directly to HIV reverse transcriptase causing chain termination

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16
Q

NNRTI adverse effects

A 
Hepatic failure
CNS issues
Teratogenic
CYP450 
Steven Johnson Syndrome
17
Q

NNRTI drugs

A

Delavirdine
Efavirenz
Nevirapine

18
Q

Protease Inhibitors suffix

A

“-navir”

19
Q

Protease Inhibitors MOA

A

Do not need to be phosphorylated to inhibit cleavage of virions

20
Q

Protease inhibitors adverse effects

A

Hyperglycemia
Dyslipidemias
Lipodystrophy
Inhibit CYP450

21
Q

Indinavir adverse effects

A

Nephrolithiasis, so patients must maintain adequate hydration

22
Q

Ritonovir adverse effects?

A

Greatest inhibition of CYP450, especially with Rifampin

23
Q

What cells do HIV target/infect?

A

CD4+ T cells
Macrophages
Dendritic Cells

24
Q

HIV virion proteins

A

p24 and p7

25
Q

HIV envelope proteins

A

gp41 and gp120

26
Q

Entry inhibitors MOA

A

Maraviroc binds/blocks the CCR5 receptor inhibit gp120 binding

27
Q

Entry inhibitor drug

A

Maraviroc

28
Q

Fusion inhibitors MOA

A

Binds to gp41 envelope proteins to block their fusion

29
Q

Fusion inhibitor drug

A

Enfuvirtide

30
Q

What HIV gene encodes for protease, reverse transcriptase, and integrase?

A

Pol gene

31
Q

Integrase inhibitors MOA

A

Binding viral integrase to not allow viral DNA to integrate into host chromosomes

32
Q

Integrase inhibitor drug

A

Raltegravir

33
Q

Integrase inhibitors adverse effect

A

Rhabdomyolysis

Sketchy Pharm- Anti-viral (3 decks)

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