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Sketchy Pharm- Anti-viral > Antiviral - others > Flashcards

Antiviral - others Flashcards

1
Q

Acyclovir MOA

A

Guanosine nucleoside analog that needs to be phosphorylated via thymidine-kinase before it can be incorporated into viral DNA to inhibit viral DNA polymerase

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2
Q

Acyclovir resistance

A

Absence of thymidine-kinase

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3
Q

Cidofovir MOA

A

Directly inhibits DNA polymerase without the need for intracellular activation

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4
Q

Cidofovir treatment

A

Resistant HSV
CMV
VZV

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5
Q

Foscarnet MOA

A

Directly inhibits viral DNA polymerase without the need for intracellular activation

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6
Q

Foscarnet treatment

A

Resistant HSV
CMV
VZV

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7
Q

What medication should you choose for daily suppressive therapy?

A

Valacyclovir b/c of it’s increased oral bioavailability

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8
Q

IV Acyclovir treatment

A

HSV and VZV
HSV encephalitis
Neonatal HSV

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9
Q

What medications can be used in the treatment of varicella zoster virus (shingles)?

A

Acyclovir
Valacyclovir**
Famciclovir**

Effective if given within 3 days of onset of symptoms

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10
Q

Adverse effects of HSV treatments?

A

Interstitial nephritis
Crystalline nephropathy
CNS issues

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11
Q

CMV treatment?

A 
Ganciclovir
Valganciclovir
Cidofovir
Foscarnet
Probenecid
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12
Q

Describe the classic CMV scenario?

A

Person complains of progressive visual impairment, non-compliant with anti-retroviral medications and a CD4 count less than 50

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13
Q

Ganciclovir MOA

A

Guanosine analog that is phosphorylated 3 times, incorporates into viral DNA, and eventually inhibits viral DNA polymerase

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14
Q

Valganciclovir MOA

A

Prodrug of ganciclovir with better bioavailability

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15
Q

Ganciclovir and Valganciclovir adverse effects?

A

Myelosuppression

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16
Q

How does CMV gain resistance and what drug should you choose if resistance occurs?

A

Mutated viral protein kinases so choose foscarnet or cidofovir.

17
Q

Foscarnet adverse effects?

A

Renal insufficiency
Hypocalcemia
Hypokalemia
Seizures

18
Q

Cidofovir adverse effects?

A

Nephrotoxicity
Metabolic acidosis
Azotemia
Proteinuria

19
Q

What should you co-administer with cidofovir?

A

Probenecid to block the tubular secretion of cidofovir and limit its toxic effects

Sketchy Pharm- Anti-viral (3 decks)

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