Antivirals

Question 1

What are examples of hepatitis B treatment drugs and what do they do

Answer 1

Tenofovir which is a nucleoside analogue

reverse transcriptase inhibitor

Question 2

What are examples of hepatitis C treatment drugs

Answer 2

Rivavirun

Boceprevir

Question 3

What does ribavirin do

Answer 3

Nucleoside analogue (purine analogue)

Question 4

What does boxeprevir do

Answer 4

Protease inhibitor

Question 5

Describe the HIV life cycle

Answer 5

1. attachment and entry
2. replication and integration
3. assembly and release

Question 6

What happens in the attachment and entry stage of the HIV life cycle

Answer 6

Viral membrane proteins interact and bind leucocyte membrane proteins causing viral capsid endocytosis via HIV GP120 binding to CD40, CCR5 or CXCR4

Question 7

What happens in the replication and integration stage of HIV

Answer 7

reverse transcriptase converts viral RNA to DNA which is integrated into host DNA

Question 8

what are different mechanisms of action of antiretroviral drugs

Answer 8

• entry inhibitors
• RT inhibitors eg Nucleoside and non nucleoside analogues
• Integrase inhibitors
• Protease inhibitors

Question 9

List some nucleotide analogue drugs

Answer 9

Ribavirin, aciclovir

Question 10

List a protease inhibitor

Answer 10

Boceprevir

Question 11

Give a neuraminidase inhibitor

Answer 11

Oseltamivir

Question 12

What are examples of entry inhibitor drugs

Answer 12

Retrovirus, leukocytes

Question 13

What are examples of RT inhibitors

Answer 13

nucleoside analogue - zidovudine

non-nucleoside analogues - efavirenz

Question 14

What are examples of integrase inhibitors

Answer 14

Raltegravir

Question 15

What are examples of protease inhibitors

Answer 15

Saquinavir