Antivirals

Question 1

Orthomyxoviridae (- strand RNA virus): Virus, drug class

Answer 1

Virus - influenza

Drug class - neuraminidase inhibitors

Question 2

Neuraminidase inhibitors -

Prototype

Answer 2

Oseltamivir
Peramivir
Zanamivir

Question 3

Herpesviridae (linear dsDNA virus): virus and drug class

Answer 3

Virus - HSV

Drug class - antiherpes nucleoside analogs, noncompetitive DNA polymerase inhibitors

Question 4

Antiherpes nucleoside analogs - prototype

Answer 4

Acyclovir. P via host and viral enzymes

Question 5

Noncompetitive DNA polymerase inhibitors

Answer 5

P by host enezymes, or no P needed

Question 6

Retroviridae (+ strand RNA virus): virus

Answer 6

HIV

Question 7

HIV CCR5 Inhibitors

Answer 7

Tropism assay required

Question 8

HIV Fusion Inhibitors

Answer 8

Injectable, rarely used

Question 9

HIV Nucleoside Reverse Transcriptase Inhibitors

Answer 9

Emtricitabine/Tenoforvir. Tenofovir - renal, bone

Question 10

HIV Non-nucleoside Reverse Transcriptase Inhibitors

Answer 10

Efavirenz. CNS effects

Question 11

HIV Integrase Strand Transfer Inhibitors

Answer 11

Dolutegravir. Few drug interactions.

Question 12

HIV Protease Inhibitors

Answer 12

Darunavir. Drug interactions., metabolic effects.

Question 13

HIV Booster agents

Answer 13

Drug interactions. Always used with PI.