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Antibacterials Flashcards

1
Q

B lactams

A

Penicillins, B lactamase inhibitors, cephalosporins, carbepenems, monobactams

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2
Q

Antimycobacterials

A

Isoniazid, rifampin

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3
Q

Penicillinase resistant penicillin spectrum

A

Nafcillin, oxacillin. Broad Gram + coverage

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4
Q

Carbapenems

A

Imipenem/cilastatin. Broad Gram +, -, and anaerobes.

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5
Q

Quinolone

A

MOA: Nuclei acid/chromatin structure inhibitors - inhibits DNA gyrase
Protype - Levofloxacin. [] dep.

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6
Q

Penicillins

A

MOA: Cell wall synthesis inhibitor
Prototype: penicillin G, ampicillin.
Narrow Gram + and _ coverage

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7
Q

Nucleic acid/chromatin structure inhibitors

A

Quinolones, metronidazole

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8
Q

Protein synthesis inhibitors

A

Aminoglycosides, tetracyclines, macrolides, clindamycin, oxazolidinone

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9
Q

Cephalosporins - 3rd gen

A

Ceftriaxone. Narrow Gram + and broad Gram - coverage.

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10
Q

Cephalosporins - 4th gen

A

Cefepime. Broad gram + and Gram - coverage.

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11
Q

Nitroimidazole

A

MOA: Nuclei acid/chromatin structure inhibitors - damages DNA
Prototype: Metronidazole
[] dep

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12
Q

Carboxy- and ureidopenicillins

A

Narrow Gram + and broad Gram - coverage

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13
Q

Cell wall synthesis inhibitors

A

B lactams, glycopeptides

vancomycin

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14
Q

Macrolides

A

MOA: Protein synthesis inhibitors, binds 50S rev
Prototype: Azithromycin. Bactericidal/bacteriostatic.

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15
Q

Natural penicillins spectrum

A

Penicillin G,K: Narrow gram positive coverage

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16
Q

β-lactamase inhibitors

A

MOA - binds penicillin-binding proteins

Prototype: clavulanic acid

17
Q

Aminopenicillins

A

Ampicillin, amoxicillin. Narrow Gram + coverage, also narrow Gram - coverage.

18
Q

Tetracyclines

A

MOA: Protein synthesis inhibitors, binds 30S rev
Prototype: Doxycycline. Bacteriostatic.

19
Q

Aminoglycosides

A

MOA: Protein synthesis inhibitors, binds 30S irrev
Prototype: Gentamicin. [] dep.

20
Q

Glycopeptides

A

MOA: inhibit cell wall synthesis
Prototype: Vancomycin

21
Q

Antifolates

A

Sulfamethoxazole/trimethoprim

22
Q

Clindamycin

A

MOA: Protein synthesis inhibitors, binds 50S
Prototype: clindamycin. Bacteriostatic.

23
Q

Cephalosporins - 1st gen

A

Cefazolin. Broad Gram + and narrow Gram - coverage

24
Q

Bacteriostatic antibacterials

A

Tetracyclines
Clindamycin
Oxazolindinone
Macrolides (primarily, variable)

25
Q

Cephalosporins - 2nd gen

A

Cefuroxim - narrow Gram + and broad Gram - coverage.

Cefoxitin - anaerobes

ID (11 decks)

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