Antivirals Flashcards
Hepatitis B - DNA or RNA virus
DNA
Hepatitis C - DNA or RNA virus
RNA
What is tropism?
Preference of viruses for certain host cells - Recognition by viral surface proteins of specific host cell surface proteins
What are the three basic approaches to treating viral diseases?
- Vaccination
- Chemo
- Stimulation of natural resistance
Amantadine
Anti-viral
Inhibits proton pump/acidification of endosome, inhibiting viral uncoating
Influenza
Oseltamivir (Tamifu)
Anti-viral
Inhibits budding & release
Take orally
Prophylactic treatment of influenza
Zanamivir (Relenza)
Anti-viral
Inhibits budding & release
Inhaled or intranasal
Prophylactic treatment of influenza
What are interferons?
Host-encoded proteins that defend against viruses by interfering with their ability to infect and replicate
Enfuviritide
Anti-viral
Entry/fusion inhibitor, blocks CD4 binding to HIV gp120
HIV
Efavirenz
NNRTI (non-nucleoside) - irreversibly inhibits RT
HIV
**gravir - Raltegravir
Anti-viral
Integrase inhibitors
HIV
**navir - Indinavir
Anti-viral
Protease inhibitors
HIV
Post-exposure prophylactic (PEP) treatment is recommended for accidental infection by HIV. What is recommended duration? A. One week B. Two weeks C. Four weeks D. One year E. Remainder of one's life
C
DNA or RNA virus? Pox
DNA
DNA or RNA virus? Polyoma
DNA
DNA or RNA virus? Polio
RNA
DNA or RNA virus? Rabies
RNA
DNA or RNA virus? SARS
RNA
DNA or RNA virus? Ebola
RNA
T or F. Enveloped viruses are MORE effective.
False
DNA or RNA virus? Influenza
RNA
Zidovudine (AZT/Retrovir)
Anti-viral
NRTI (nucleotide inhibitor of RT) - binds active site of polymerase, mimics nucleotides, and gets incorporated into RNA/DNA chain, preventing elongation
HIV
Acyclovir
Anti-viral
NRTI (nucleotide inhibitor of RT) - binds active site of polymerase, mimics nucleotides, and gets incorporated into RNA/DNA chain, preventing elongation
Herpes
