Antivirals

Question 1

Give 3 complications from varicella infection

Answer 1

CMV
Congenital limb anomalies (1st. 2nd trimester)
MRSA infection superimposed
Viral Pneumonia

Question 2

Give the antiviral compound in Valaciclovir?

Answer 2

Acyclovir

Question 3

Give the antiviral compound in Famciclovir?

Answer 3

Peninciclovir

Question 4

Give the antiviral compound in Valganciclovir?

Answer 4

Valganciclovir

Question 5

What enzyme is responsible for phosphorylation of acyclic nucleoside so that their antiviral activity for HSV and VZV?

Answer 5

Viral Thymidine Kinase

Question 6

guanosine analogue antiviral drug that is also a prototype anti-herpes drug with good CSF penetration

Answer 6

Acyclovir

Question 7

Mechanisma of action of acyclovir

a. Integrase inhibition
b. Protease Inhibition
c. DNA chain terminator
d. NOTA

Answer 7

C

Question 8

True about acyclovir EXCEPT

a. Exhibits low activity for Cytomegalovirus
b. Triphosphate form is the active drug
c. Needed in children with varicella lesions
d. Safe for pregnant women

Answer 8

C

Question 9

True about acyclovir EXCEPT

a. IV acyclovir is for HSV and VZV
b. Oral acyclovir has low availability
c. Topical acyclovir is used for immunocompromised hosts with HSV infection
d. NOTA

Answer 9

D

Question 10

What is common among TK-negative mutants, TK-partial mutants, TK altered mutants and DNA pol mutants?

Answer 10

Acyclovir resistant

Question 11

L-valyl ester of acyclovir

Answer 11

Valacyclovir

Question 12

[Class] Tenofivir

Answer 12

Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Question 13

[Class] Efavirenz

Answer 13

Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI)

Question 14

[Class] Atazanavir

Answer 14

Protease Inhibitor

Question 15

[Class] Maraviroc

Answer 15

CCR5 Inhibitor

Question 16

[Class] Raltegravir

Answer 16

Integrase Inhibitors

Question 17

[Class] Emtricitabine

Answer 17

NRTI

Question 18

[Class] Encuvirtide

Answer 18

Fusion inhibitor

Question 19

[Class] Zidovudine

Answer 19

NRTI

Question 20

[Class] Lamivudine

Answer 20

NRTI

Question 21

[Class] Nevirapine

Answer 21

NNRTI

Question 22

[Class] Rotanivir

Answer 22

Protease inhibitor

Question 23

Adverse effects of NRTI

Answer 23

LDH
Lactic acidosis
Dyslipidemia
Hepatic steatosis

Question 24

Additional adverse reactions for Zidovudine

Answer 24

MN
Macrocytic anemia
Neutropenia

Question 25

Contraindications for Zidovudine

Answer 25

Concurrent stvudine and myelosupressive agnets

Question 26

Differentiate MOA of NRTI and NNRTI

Answer 26

reverse transcriptase inhibition by NRTI is via competition while NNRTI inhibits reverse transcriptase via non-competitive inhibition

Question 27

What is the most recommended NNRTI?

Answer 27

Nevirapine