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Ther 201 Exam 3 > Antiparasitics > Flashcards

Antiparasitics Flashcards

1
Q

What is the drug of choice for tetanus treatment?

A

Metronidazole

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2
Q

What is the MOA of metronidazole?

A

N group accepts e- from ferrodoxin of anaerobic parasite -> Reductive bioactivation produces cytotoxic products -> react with protein and DNA causing damage and death to parasite

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3
Q

Indications of Metranidazole EXCEPT

a. Bacteroides fragilis caused meningitis
b. trichomoniasis
c. Giardiasis
d. Gardnerella vaginalis infection
e. NOTA

A

E

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4
Q

Mixed Amebicide include

a. Metronidazole
b. Diloxonide
c. Paramomycin
d. NOTA

A

A. B and C are luminal amebicides

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5
Q

What is the indication for diloxanide furoate?

A

asymptomatic cyst passers combined with metronidazole

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6
Q

What are thew adverse drug reactions for diloxanide furoate?

A

Flatulence
Dry mouth
Pruritus

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7
Q

What organisms cause Malaria?

A

Plasmodium falciparum
P. vivax
P. ovale
P. malariae

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8
Q

P. falciparum is resistant to the ff drugs EXCEPT

a. Artemether
b. chloroquine
c. fansidar
d. Quinine

A

D

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9
Q

Chemotherapy for Malaria include

a. Chloroquine
b. Mefloquine
c. Primaquine
d. Quinine
e. NOTA

A

C

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10
Q

What drugs are given for malaria prophylaxis?

A

Mefloquine

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11
Q

Give 6 blood schizonticides

A 
CMFQAL
Chloroquine
Mefloquine
Fansidar
Quinine
Artemisinin
Lumefantrine
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12
Q

The ff are true about Lumefantrine EXCEPT

a. Has activity against P. falciparum
b. Drug levels may be altered by those affecting CYP3A4
c. Oral absorption is impaired by food
d. NOTA

A

C; absorption is improved by food

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13
Q

Which antimalarial drug causes cinchonism?

A

Quinine, from the Cinchona tree
Cicnchonism: GHVBT
GI distress, Headache, Vertigo, Blurred Vision, Tinnitus

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14
Q

Coartem is combined __________ and __________

A

Arthemeter - Lumefantrine

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15
Q

What is the MOA of quinine?

A

Complexes with dsDNA to prevent its separation therefore blocking DNA replication

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16
Q

ADR of Quinine EXCEPT

a. skin rashes
b. angioedema
c. hemolysis with G6PD deficiency
d. leucopenia
e. NOTA

A

e

17
Q

Drug of choice for P. vivax

A

Chloroquine

18
Q

MOA of chloroquine

A

Prevents biocrystallization of parasitic heme into hemozoin causing build up of heme leading to lysis of parasite

19
Q

T/F Like Quinine, Chloroquine and Primaquine can also cause hemolysis in G6PD

A

True

20
Q

FANSIDAR is a combination of

A

Pyrimethamine and Sulfadoxine

21
Q

Which antimalarial drug can cause folic acid deficiency

A

Pyrimethamine

22
Q

Which is the best antihelminthic drug and usual drug of choice?

A

Albendazole

23
Q

Give 5 parasites sensitive to albendazole

A 
PCHAT
Pinworm
Capilaria
Hookworm
Ascaris
Trichuris
24
Q

What is the MOA of Albendazole and Mebendazole?

A

inhibit microtubule synthesis thus irreversibly impairing glucose uptake and ATP formation

25
Q

Albendazole
Mebendazole
Pyrantel Pamoate show high cure rates against which parasite?

A

Ascaris lumbricoides

26
Q

Mebendazole is effective for which parasites?

A

ATE
Ascaris
Trichuris
Enterobius

27
Q

T/F Mebendazole should be taken after a fatty meal

A

F; fatty meals increase oral availability of mebendazole and we don’t want that. Thus, it should be taken in an empty stomach

28
Q

Which antihelminthic paralyzes worm by stimulating the nicotinic receptors at the neuromuscular joints causing super contraction of muscles followed by depolarization which induces paralysis?

A

Pyrantel Embonate

29
Q

Pyrantel Embonate is the drug of choice for

A

EHA
Enterobious
Hookworm
Ascaris

30
Q

What is the drug of choice for Filariasis?

A

Diethylcarbamazine

31
Q

What is the drug of choice for schistosomiasis?

A

Praziquantel

32
Q

What is the drug of choice for tapeworm?

A

Praziquantel

Ther 201 Exam 3 (6 decks)

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