Antivirals

Question 0

What is the MOA of fusion inhibitors?

Answer 0

Inhibits viral fusion with cell membrane

Enfuviritide

Question 1

What is the MOA of cellular chemokine receptor antagonists?

Answer 1

Prevent viral entry into cell

Maraviroxc

Question 2

What is the MOA of integrase inhibitors?

Answer 2

Inhibits incorporation of viral DNA into genome

Raltegravir

Question 3

What is the MOA of non-NRTI?

Answer 3

Binds directly to reverse transcriptase and inhibits RNA and DNA dependent DNA polymerase
End in -virine

Question 4

What is the MOA of of NRTI?

Answer 4

Analog of D-nucleosides which inhibit RT and therefore inhibits DNA chain elongation and therefore DNA growth

Question 5

What is the MOA of of protease inhibitors?

Answer 5

Bind viral proteases essential for DNA synthesis

-avir

Question 6

Nucleoside analog reverse transcriptase inhibitor

Answer 6

Nucleotide analog which inhibits RT causing DNA chain termination

Question 7

Which antiretroviral agent is associated with injection site reaction?

Answer 7

Fusion inhibitor

Question 8

Which antiretroviral agents are cyp inhibitors?

Answer 8

Protease inhibitors

Potentates the effect of other HIV drugs by blocking their clearance

Question 9

Identify the two antivirals for influenza

Answer 9

First generation:

1. ) Amantidine
2. ) Ramantadine

Neuraminindase inhibitors

1. ) Oseltamivir
2. ) Zanamivir (inhaled)

Question 10

What is the category of drugs used to treat HSV?

Answer 10

Purine nucleoside analogs

Question 11

Three kinds of herpetic infections

Answer 11

Genital–Acyclovir, Famcyclovir, Valacyclovir
Cold sores–Acyclovir for immunocompromised and Pencyclovir for adults
Varicella Zoster–Acyclovir, Valacyclovir

Question 12

Treatment for CMV

Answer 12

Foscarnet
Nucleoside analogs: Ganciclovir, Valganciclovir
DNA polymerase inhibitor: Cidofovir