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Pharmacology > Antivirals > Flashcards

Antivirals Flashcards

1
Q

what is the combo of tenofovir and emtricitabine used for

A

pre exposure prophylaxispost exposure prophylaxis

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2
Q

what are some adverse effect of emtricibabine

A

hyperpigmentation of the palms and skin discoloration

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3
Q

what are the adverse effects with Zidovudine

A

bone marrow supression

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4
Q

what are special consideration for lamivudine

A

Epirvir HBVresistance is quite common

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5
Q

What is truvada

A

emtricitabine and tenofovir1 tab PO dialy

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6
Q

what is atripla

A

emtricitabine, tenofovir, efavirenz1 tab PO daily

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7
Q

What is stribild

A

emtracitabine, tenofivir, elvitegravir, cobivistat1 tab PO dialy

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8
Q

What is dosing like for efaviranz

A

600mg PO at bed time

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9
Q

How should you take efaviranz

A

empty stomach

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10
Q

what are the averse effects with Efaviranz

A

CNS effectsstops after 2-4 wksrashincreased LFTTeratogenfalse positive weed test

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11
Q

what is rilpivirine not used for and what should you avoid using it with?

A

high viral loadsProton pump inhibitors

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12
Q

what are some adverse effects with Nevirapine

A

hepatits and fetal hepatic necrosis

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13
Q

What are the special considerations with Atazanavir and what are the adverse effects

A

avoid with proton pump inhibtorsindirect hyperbiliruninemialack of effects on lipids

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14
Q

what is a special precautions with Darunavir

A

caution with sulfa allergyRash

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15
Q

what are the adverse effects with Raltegravir& Stribild

A

increased creatine kinase

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16
Q

when do antivirals need to be administered for HSV and VZV

A

Acyclovir48-72hr with onset of rash

17
Q

what is the blackbox warning with Ganciclovirwhat are the special considerations

A

treats CMVbone marrow toxHydrate aggressivelymonitor renal functionavoid skin contact alkaline and teratogenic

18
Q

what is the the drug of choice for Tx and Px of CMV

A

Valganciclovir

19
Q

what are the special considerations with Valganciclovir

A

PO onlylook alike sound alike with Valcyclovir and Valganciclovir

20
Q

what is the adverse effect with Foscarnet what does it treat

A

treat CMVhighly nephrotoxic

21
Q

what agents are used to treat Hep B virus infection

A

Adefovir, Lamivudine, entecavir, telbivudine, tenofovirinterferon alfa

22
Q

What are the adverse effects with Entecavir

A

dizziness and fatigue

23
Q

what are the adverse effects of interferon for HVC infection

A

flu-like syndromeH/A, myalgia, arthralgias, fatigue, malaise, fever, chills,improves as treatment continues

24
Q

what are the special considerations with interferons for HVC

A

contraindication to therapyhepatic deompensationautoimmune diseasehistory of arrhythmiapregnancy

25
Q

what are the adverse effects with ribavirin

A

used for HCVhemolytic anemiateratogeniccan’t handle cansules if prego.

26
Q

what are the special consideration with sofosbuvir

A

Used for HVC$1,000 per tabpan genotypic activitymake it possible to treat some pts with out interferon

27
Q

how is simeprivir takenwhat are special consideration of simeprevir

A

used for HCVwith foodassessment of Q80K mutationdrug interactions

28
Q

what is the best method of routine prevention

A

inactivated influenza vaccine

29
Q

what are the adverse effects with amantadine

A

CNS tox increase with elderly

30
Q

what amantadine use to treat now

A

no longer used to treat influenza prophylaxisused to treat parkinsons disease and drug induced EPS

31
Q

Rimantadine adverse effects

A

less CNS adverse effects

32
Q

what can actually happen to disinfectant and antispectic

A

they may become contaminated with spore or bacteria and transmit infection

Pharmacology (14 decks)

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