Antivirals Flashcards
What is the mechanism of zanamivir/oseltamivir
Inhibit influenza neuraminidase
Decrease release of progeny virus
What is zanamivir/oseltamivir used for
Influenza A/B
What is the mechanism of ribavirin
Inhibits IMP dehydrogenase –> inhibits synthesis of guanine nucleotides
What is ribavirin used for
RSV
Chronic Hep C
What are toxicities to ribavirin
Hemolytic anemia
Severe teratogen
What is the mechanism of acyclovir
Guanosine analog
Inhibits viral DNA polymerase by chain termination
What is acyclovir used for
HSV
VZV
What is the mechanism of gangciclovir
Guanosine analog
Inhibits viral DNA polymerase
What is gangciclovir used for
CMV
What are toxicities to gangciclovir
Leukopenia
Neutropenia
Thrombocytopenia
Renal toxicity
What is the mechanism of foscarnet
Binds to the pyrophosphate binding site of the enzyme
What is foscarnet used for
CMV retinitis when gangciclovir fails
What are toxicities to foscarnet
Nephrotoxicity
What is the mechanism of cidofovir
Inhibits viral DNA polymerase
Does not require phosphorylation by viral kinase
What is cidofovir used for
CMV retinitis
What are toxicities to cidofovir
Nephrotoxicity
