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CMBM Exam 3 CL > Antiviral Drugs (Cadet's Study Guide) > Flashcards

Antiviral Drugs (Cadet's Study Guide) Flashcards

1
Q

What drugs are used to treat Influenza?

A

Amantadine, Rimantadine, Oseltamivir, Zanamivir

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2
Q

What are the mechanisms of anti-influenza drugs?

A

Uncoating inhibitors block M2 ion channels; neuraminadase inhibitor

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3
Q

Which drugs have the following mechanism: uncoating inhibitors that block M2 ion channels? What virus does it work against?

A

Amantadine & Rimantadine - Influenza

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4
Q

Which drugs have the following mechanism: neuraminadase inhibitor? What virus does it work agains?

A

Oseltamivir & Zanamivir - Influenza

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5
Q

What drug is used to treat HSV?

A

Acydovir

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6
Q

What drug is used to treat VZV?

A

Acydovir

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7
Q

What drugs are used to treat CMV

A

Ganicyclovir & Cidofir

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8
Q

What is the mechanism of anti-HSV drugs?

A

Nucleoside analog - added to growing chain of viral DNA, resulting in chain termination.

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9
Q

What is the mechanism of anti-VZV drugs?

A

Nucleoside analog - added to growing chain of viral DNA, resulting in chain termination.

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10
Q

What are the mechanisms of anti-CMV drugs?

A

Nucleoside analog - added to growing chain of viral DNA, resulting in chain termination; cytosine nucleotide analog.

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11
Q

Which drugs have the following mechanism: Nucleoside analog - added to growing chain of viral DNA, resulting in chain termination? What viruses do they work against?

A

Acyclovir - HSV & VZV; Ganicyclovir - CMV

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12
Q

Which drug has the following mechanism: cytosine nucleotide analog? What virus does it work against?

A

Cidofir - CMV

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13
Q

What drug is used to treat RSV?

A

Palvizumab

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14
Q

What is the mechanism of anti-RSV drugs?

A

Monoclonal antibody to RSV F fusion protein.

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15
Q

Which drug has the following mechanism: monoclonal antibody to RSV F fusion protein? What virus does it work against?

A

Palvizumab - RSV

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16
Q

What is the broad spectrum anti-viral drug?

A

Ribavirin

17
Q

What is the mechanism of the broad spectrum drug?

A

GTP nucleoside analog interferes with viral RdRp.

18
Q

What viruses does the broad spectrum drug work against?

A

RSV, HCV, Vaccinia, Monkeypox, other viruses.

19
Q

Which drug has the following mechanism: GTP nucleoside analong that interferes with viral RdRp? What viruses does it work against?

A

Ribavirin - RSV, HCV, Vaccinia, Monkeypox, other viruses.

20
Q

What drug is used to treat HCV?

A

Type I IFN

21
Q

What is the mechanism of anti-HCV drugs?

A

Immune enhancement via immunomodulatory means: increases MHC-I expression of infected cells, leading to enhanced CD8 toxicity.

22
Q

Which drug has the following mechanism: Immune enhancement via immunomodulatory means: increases MHC-I expression of infected cells, leading to enhanced CD8 toxicity? What virus does it work against?

A

Type I IFN - HCV

23
Q

What drugs are used to treat HBV?

A

Lamivudine & Tenofovir

24
Q

What are the mechanisms for anti-HBV drugs?

A

Reverse transcriptase inhibitor; reverse transcriptase & DNA polymerase inhibitor.

25
Q

Which drug has the following mechanism: reverse trascriptase inhibitor? What virus does it work against?

A

Lamivudine - HBV

26
Q

Which drug has the following mechanism: reverse transcriptase & DNA polymerase inhibitor?

A

Tenofovir - HBV

27
Q

What drugs are used to treat HIV?

A

Zidovudine (ZDV/AZT), Lamivudine, Efavirenz, Ritonavir, Raltegravir, Enfuvirtide

28
Q

What are the mechanisms for anti-HIV drugs?

A

Nucleoside reverse transcriptase inhibitor (added to growing chain; binds at RT active site), non-nucleoside reverse transcriptase inhibitor (binds directly to and alters RT), protease inhibitor (binds to HIV protease), integrase inhibitor (competitive inhibitor of Mg2+ & Mn2+, essential cofactors for integrase), fusion inhibitor (binds gp41 of HIV-1 envelope and prevents viral fusion and entry).

29
Q

Which drugs have the following mechanism: nucleoside reverse transcriptase inhibitor (added to growing chain; binds at RT active site? What virus does it work against?

A

Zinovudine (ZDV/AZT) & Lamavudine - HIV

30
Q

Which drug has the following mechanism: non-nucleoside reverse transcriptase inhibitor (binds directly to and alters RT)? What virus does it work against?

A

Efavirenz - HIV

31
Q

Which drug has the following mechanism: protease inhibitor (binds to HIV protease)? What virus does it work against?

A

Ritonavir - HIV

32
Q

Which drug has the following mechanism: integrase inhibitor (competitive inhibitor of Mg2+ & Mn2+, essential cofactors for integrase)? What virus does it work against?

A

Raltegravir - HIV

33
Q

Which drug has the following mechanism: fusion inhibitor (binds gp41 of HIV-I envelope and prevents viral fusion and entry? What virus does it work against?

A

Enfuvirtide - HIV

CMBM Exam 3 CL (9 decks)

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