Antiviral drugs

Question 1

Count the antiviral current classes ?

Answer 1

1- DNA polymerase inhibitors.
2- Anti-hepatitis
3- Anti influenza agents.
4- Antiretroviral agents
5- Agents Rx Cytomegalovirus.

Question 2

Subclasses of anti-retrovirals ?

Answer 2

• nucleoside reverse transcriptase inhibitors
• non-nucleoside reverse transcriptase inhibitors.
• protease inhibitors.
• fusion inhibitors.

Question 3

DNA-polymerase inhibitors drugs ?

Used to Rx Herpes simplex &Varicella-zoster virus (chickenpox)

Answer 3

Acyclovir, Valacyclovir, Famciclovir, Penciclovir, Foscarnet, Triflurifine.

Question 4

A side note in terms of chickenpox in children &analgesic/fever symptomatic treatment ?

Answer 4

Aspirin is highly contraindicated, with VZV it could cause fatal liver &brain diseases. Use acetaminophen.

Antivirals effective against VZV aren’t currently used in healthy children, unless another affection that may cause complications is present.

Question 5

Difference entre varicelle &rougeole ?

Chickenpox (Jiji’s) &measles respectively.

Answer 5

Les éruptions cutanées de rougeole se localisent à l’intérieur des joues et se propagent progressivement sur le visage, avant de descendre sur les épaules et le torse. Les bras, le ventre et les jambes finissent par être touchés également.

les boutons de varicelle se localisent quant à eux suivent un autre développement : ils apparaissent d’abord au niveau du torse avant d’envahir le visage, le cou et le reste du corps. Il arrive que des boutons se retrouvent même sur le cuir chevelu !

Ces petits ulcères plats démangent énormément et causent bien des tracas pour les plus petits. Après quelques jours, ils se transforment en croûtes qui disparaissent en moyenne au bout d’une semaine.

Question 6

Agents that Rx cytomegalovirus ?

Answer 6

Cidofovir, Foscarnet, Fomivirsen, Ganciclovir, Valanciclovir.

Question 7

Cytomegalovirus ?

Answer 7

A common virus that can infect anyone. Rarely shows symptoms. Once infected, virus is carried throughout life &there is no cure for it. It only manifests in a weakened immune system terrain &spreads from one to another during its reactivation through body fluids.

Question 8

Mononucleosis ?

Answer 8

The incriminated virus in mononucleosis is Epstein-Barr virus EBV. Called the kissing disease because it spread via saliva &other body fluids. Rarely fatal, once infected, you are immunized. Incubation period goes up to 6 weeks, symptoms are fever, night sweats, swollen lymph nodes. Aside to obvious viral infection symptoms : headaches, muscle weakness &fatigue.

Question 9

Antiretroviral agents, nucleoside reverse transcriptase inhibitors ?

Answer 9

*Nucleoside reverse transcriptase inhibitors :

Abacavir, Didanosine, Lamivudine, Stavudine, Zidovudine, Zalcitabine.

Question 10

Antiretroviral agents, non-nucleoside reverse transcriptase inhibitors ?

Answer 10

*Non-nucleoside reverse transcriptase inhibitors :

Delavirdine, Efavirenz, Nevirapine.

Question 11

Antiretroviral agents, protease inhibitors ?

Answer 11

*Protease inhibitors : Amprenavir, Indinavir, Nelfinavir, Ritonavir, Saquinavir.

Question 12

Antiretroviral agents, fusion inhibitors ?

Answer 12

Enfuvirtide.

Question 13

Anti-hepatitis agents ?

Answer 13

Adefovir, Interferon, Lamivudine, Ribavirin.

Question 14

Anti-infulenza agents ?

Answer 14

Amantadine, Rimantadine, Oseltamivir.