Anti-emetics

Question 1

Antiemetics classes ?

Answer 1

Anticholinergics, antihistamines, benzodiazepines, D2 antagonists, glucocorticoids, neurokinin I antagonists, phenothaizines, selective 5-HT3 antagonists.

Question 2

*Anticholinergics ?

Answer 2

Hyoscine

Question 3

*Antihistamines H-1 antagonists ?

Answer 3

Cyclizine, hydroxyzine, meclizine, promethazine, dimenhydrinate, diphenylhydramine.

Question 4

*Benzodiazepines (only for n&v induced by chemotherpay) ?

Answer 4

Diazepam

Nausea was reduced and vomiting decreased after the antiemetic treatment with 5HT3RA + Dexamethasone and diazepam. The only side effect related to this antiemetic therapy was light somnolence. Antiemetics combined with diazepam might be a useful therapy against delayed nausea and vomiting induced by anticancer agents.

Question 5

*D-2 antagonsits ?

Answer 5

Domperidone, metoclopramide.

Question 6

*Glucocorticoids ?

Answer 6

Dexamethasone, methylprednisolone.

Question 7

*Neurokinin-I antagonists ?

Answer 7

Aprepitant.

Question 8

*Phenothazines ?

Answer 8

Chlorpromazine, prochlorperazine.

Question 9

*Selective 5-HT3 antagonists ?

Answer 9

Granisetron, Ondansetron, dolasetron, palonosetron.