antiv Flashcards
What is the brand name for Acyclovir?
Zovirax, Various
What is the drug class for Acyclovir
Viral DNA Polymerase Inhibitor
What are the major contraindications for Acyclovir?
Hypersensitivity to acyclovir or valacyclovir
What are the common adverse effects for Acyclovir?
Malaise
What is the black box warning for Acyclovir?
None
What are the rare but serious adverse effects for Acyclovir?
Severe hypersensitivity, renal failure, TTP
What are the key counseling points for Acyclovir?
Complete full course of therapy. Ensure adequate hydration. For HSV, initiate treatment as soon as possible at first sign of lesion (treatment most effective if initiated within 24 h of lesion onset). For VZV, treatment should begin within 24 h of appearance of rash. Symptoms should improve within 2-3 d; if they worsen, seek follow-up with HCP. If using for prophylaxis or suppression of infection, this medication should reduce the number of breakouts. Maintain adequate hydration during therapy.
What is the mechanism of action of Acyclovir?
Acyclovir is an acyclic nucleoside analogue of deoxyguanosine that is selectively phosphorylated by the virus-encoded thymidine kinase to its monophosphate form. Cellular enzymes then convert the monophosphate to the active antiviral acyclovir triphosphate, which competitively inhibits viral DNA synthesis by inactivation of viral DNA polymerase and incorporation into and termination of viral DNA replication. Acyclovir has potent activity against HSV I and II and HZV (VZV).
What is the brand name for Atazanavir?
Reyataz, Various
What is the drug class for Atazanavir?
Antiretroviral Agent, Protease Inhibitor
What is the indication for Atazanavir?
What is the indication for Acyclovir?
