antifug Flashcards
What is the brand name for Fluconazole?
Diflucan
What drug class is Fluconazole in?
Imidazole Antifungal
What are the indications for Fluconazole?
Candidal vulvovaginitis (Uncomplicated, Complicated), Candidiasis, Cryptococcal meningitis, Oropharyngeal candidiasis
What is the mechanism of action of Fluconazole?
Inhibits (CYP51) biosynthesis of ergosterol or other sterols, damaging the fungal cell wall membrane and
altering its permeability
What are the black box warnings for Fluconazole?
None
What are the major contraindications for Fluconazole?
Hypersensitivity, Concurrent ergot alkaloids, CYP3A4/5 substrates that prolong QTc
What are the common adverse drug reactions for Fluconazole?
Headache
What are the rare but serious adverse drug reactions for Fluconazole?
Stevens-Johnson syndrome, Arrhythmias (prolonged QTc interval), Adrenal suppression, Agranulocytosis, Seizures, Elevated LFTs, Hypokalemia
What are the key counseling points for Fluconazole?
Many medications, including OTC medications, interact with fluconazole. Do not take any new medications without consulting your doctor or pharmacist. If taking a weekly dose, take on same day and time each week.
What is the brand name of Ketoconazole?
Nizoral
What are the indications for Ketoconazole?
Candidiasis, Dandruff, Pityriasis
versicolor, Seborrheic dermatitis, Tinea (corporis, cruris, pedis)
What drug class is Ketoconazole in?
Imidazole Antifungal
What is the mechanism of action of Ketoconazole?
Inhibits (CYP51) biosynthesis of ergosterol or other sterols, damaging the fungal cell wall membrane and altering its permeability.
What are the major contraindications for Ketoconazole?
Hypersensitivity
What are the black box warnings for Ketoconazole?
None
What are the rare but serious adverse drug reactions for Ketoconazole?
Rash, Hair loss
What are the common adverse drug reactions for Ketoconazole?
Application site rxn with foam
What are the key counseling points for Ketoconazole?
Apply thin layer to affected area of skin. Skin should be intact. Do not get in your eyes, nose, mouth, or vagina. Do not wash the areas where you applied this medicine for at least 3 h after application. Cosmetics (makeup or sunscreens) may be put on the affected areas
for 20 mins after application. Topical products are alcohol based and flammable immediately after application.
Are Azoles safe to use during pregnancy?
No - High risk in first trimester =
Category D
What is the brand name for Nystatin Systemic?
Bio-Statin
What drug class is Nystatin Systemic in?
Polyene Antifungal
What are the indications for Nystatin Systemic?
GI candidiasis (nonesophageal) and Oropharyngeal candidiasis
What is the mechanism of action of Nystatin Systemic?
Binds to the sterols
in fungal cell walls, damaging the fungal cell wall membrane and altering its permeability for leakage of cellular contents.
What are the major contraindications for Nystatin Systemic?
Hypersensitivity
What are the black box warnings for Nystatin Systemic?
None
What are the common adverse drug reactions for Nystatin Systemic?
None known, 1-10% : GI distress, Nausea, Vomiting, Constipation, Oral irritation
What are the rare but serious adverse drug reactions for Nystatin Systemic?
Rash
What are the key counseling points for Nystatin Systemic?
Store the tablets
at room temperature. Shake suspension well before using.
What is the brand name for Nystatin Topical?
Mycostatin
What drug class is Nystatin Topical in?
Polyene Antifungal
What are the indications for Nystatin Topical?
Candidiasis of skin
What is the mechanism of action of Nystatin Topical?
Binds to the sterols
in fungal cell walls, damaging the fungal cell wall membrane and altering its permeability allowing for leakage of cellular contents.
What are the major contraindications for Nystatin Topical?
Hypersensitivity
What are the black box warnings for Nystatin Topical?
None
What are the common adverse drug reactions for Nystatin?
None known, 1-10% : Dry skin, Skin irritation
What are the rare but serious adverse drug reactions for Nystatin?
Rash, Hypersensitivity reactions, Stevens-Johnson Syndrome
What are the key counseling points for Nystatin?
Apply to the affected area of skin. Skin should be intact. Do not get it in eyes, nose, or mouth. Avoid occlusive dressings, tight-fitting diapers, and plastic pants if using on diaper area of children.
What is the brand name for Terbinafine?
Lamisil
What drug class is Terbinafine in?
Allylamine Antifungal
What are the indications for Terbinafine?
Activity against dermatophytes,
Yeasts (e.g., candida), and Dimorphic fungi
What is the mechanism of action of Terbinafine?
Allylamine that inhibits
ergosterol synthesis through inhibition of squalene epoxidase to destabilize the fungal cell membrane
What are the major contraindications for Terbinafine?
Hypersensitivity, Existing liver disease
What are the common adverse drug reactions for Terbinafine?
Local irritation for topical
What are the rare but serious adverse drug reactions for Terbinafine?
Hepatotoxicity with systemic, Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
What are the key counseling points for Terbinafine?
Possible temporary alterations to taste and smell - can be taken with or without food/water.
