Antituberculosis agents Flashcards

1
Q

what causes tuberculosis

A

mycobacterium

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2
Q

are Isoniazid (INH), ethambutol, pyrazinamide (PZA), rifampin, streptomycin first line or second line?

A

first line antituberculosis agents

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3
Q

are Capreomycin, cycloserine, ethionamide, kanamycin, para-aminosalicylic acid (PAS) first line or second line?

A

2nd

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4
Q

drug of choice for TB. Metabolized in the liver through acetylation (watch for slow acetylators-accumulation of the drug. Leads to a longer half life). Used alone or in combination with other agents

A

Isoniazid

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5
Q

Side effects of Isoniazid

A

peripheral neuritis, hepatotoxicity

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6
Q

Effectiveness depends on: type of infection, adequate dosing, sufficient duration of treatment, selection of effective drug combination

A

Antituberculosis Therapy

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7
Q

side effects of Antituberculosis Therapy

A

Fatigue, N & V, numbness/tingling of extremities, fever, loss of appetite, depression, jaundice neuritis, blindness (ethambutol), discoloration of urine and stools (reddish orange), hepatitis (rifampin)

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