Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Sys Pharmaco CVS > Antithrombotic Agents > Flashcards

Antithrombotic Agents Flashcards

1
Q

Antithrombotic Agents types?

A
  1. Antiplatelet Agents

2. Anticoagulants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Antiplatelet Agents types?

A
  1. NSAIDs
  2. Thienopyridine
  3. GPIIb/IIIa
    Antagonists
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

NSAIDs drugs?

A

Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

NSAIDs Mechanism of Action?

A

• Inhibition of COX pathways = ↓ prostanoid synthesis

  • ↓ TXA2 preventing platelet aggregation
  • ↓ PGI2 antithrombotic activity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

NSAIDs Side Effects and Contraindications?

A
  • GIT Bleeding
  • Peptic Ulcer
  • Pseudoallergy reactions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Thienopyridine drugs?

A

Ticlodipine, Clopidogrel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Thienopyridine Mechanism of Action?

A

• Inhibition of platelet aggregation by antagonism of ADP receptors

  • P2Y1: change in platelet conformation
  • P2Y12: ↓ cAMP, ↓ ADP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Thienopyridine Side Effects and Contraindications?

A
  • Well tolerated

* Mild nausea, dyspepsia, rashes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

GPIIb/IIIa Antagonists drugs?

A

Abciximab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

GPIIb/IIIa Antagonists Mechanism of Action?

A

• Antagonism of GPIIb/IIIa receptor and therefore prevent

platelet aggregation and activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

GPIIb/IIIa Antagonists Side Effects and Contraindications?

A
  • Bleeding, Thrombocytopenia

* Allergic reaction (to mouse component)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Anticoagulants types?

A
  1. Heparin
  2. Warfarin
  3. Thrombolytics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Heparin drugs?

A
  • HMW, LMW, Synthetic heparin

* Parenteral administration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Heparin Mechanism of Action?

A
  • Binds to antithrombin and increases its activity in cleaving clotting factors (2, 7, 9, 10)
  • Increased TFPI release
  • Antidote = protamine sulphate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Heparin Side Effects and Contraindications?

A
  • Increased bleeding tendency
  • Allergic reaction (switch to synthetic heparin)
  • Heparin induced thrombocytopenia (HIT)
  • Osteoporosis and increased fracture risk
  • Reversible alopecia, mineralocorticoid deficiency
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Warfarin drugs?

A

• Given orally

• Drug interactions – hepatic enzyme
inducer / inhibitor / protein binding

17
Q

Warfarin Mechanism of Action?

A
  • Inhibition of VKCOR1 leading to decreased Vitamin K synthesis and eventual depletion of clotting factors
  • Slow onset of action as existing clotting factors depleted
18
Q

Warfarin Side Effects and Contraindications?

A
  • Bleeding
  • Cutaneous necrosis
  • Teratogen
19
Q

Thrombolytics drugs?

A

• Streptokinase, Urokinase, Tissue plasminogen activator

20
Q

Thrombolytics Mechanism of Action?

A

Breaks down the fibrin clot

21
Q

Thrombolytics Side Effects and Contraindications?

A

Bleeding

Sys Pharmaco CVS (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions