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Neuropharma > Antithrombotic > Flashcards

Antithrombotic Flashcards

1
Q

Mechanism of action of Ticagrelor

A

ADP inhibitor

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2
Q

Half life of apixaban

A

12 hours

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3
Q

Mechanism of action of Rivaroxaban

A

Direct IXa inhibitor

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4
Q

These antiplatelet inhibit platelet aggregation by inhibiting ADP pathway of platelet

A

Ticlopidine and Clopidogrel

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5
Q

Mechanism of action of cilostazol

A

Phosphodiesterase inhibitor

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6
Q

Half life of Dabigatran

A

12-17 hours

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7
Q

Mechanism of warfarin

A

Block carboxylation of glutamate residue in: Prothrombin, F VII, IX and X and protein C/S
Inhibit vitamin K epoxidase reductase

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8
Q

What is the mechanism of action of Dypriridamole

A

Inhibit adenosine uptake and cGMP phosphodiesterase activity

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9
Q

Mechanism of action of Dabigatran

A

Direct thrombin inhibitor

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10
Q

What blood parameter dabigatran increases

A

PTT

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11
Q

Activity of heparin depends on the endogenous anticoagulant ____________

A

Antithrombin

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12
Q

Anithrombin inhibits the following:

A

Clotting factor proteases
IIa
IXa
Xa

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13
Q

Pharmacodynamic mechanism of VKA

A
  1. Synergism - impaired hemostasis and reduced clotting factors
  2. Competitive antagonism - Vit K
  3. Alteration of physiologic loop for VKA
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14
Q

Half life of warfarin

A

36 hours

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15
Q

Mechanism of action of Apixaban

A

Direct IXa inhibitor

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16
Q

This is a monoclonal antibody against IIb/IIIa complex

A

Abciximab

17
Q

What medication increases level of rivaroxaban

A

Ketoconazole

18
Q

Reversal of Heparin

A

Protamine Sulfate

19
Q

Drug interaction of VKA

A

Inducer of CYP2CA

BDZ and RIfampicin - decreases the anticoagulant activty
Cholestyramine - binds to VKA and reduces absorption

20
Q

What is the mechanism of action of ASA

A

Inhibit the synthesis of thromboxane A2 by irreversible acetylation of enzyme COX

21
Q

Toxicity of heparin

A

Bleeding
Alopecia
Heparin Induced thrombocytopenia

22
Q

Reversal agents for VKA

A

Vit K1
FFP
rFVIIa

23
Q

Maintenance dose of VKA

A

5-7mg/d

Neuropharma (6 decks)

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