Antithrombotic Flashcards
Mechanism of action of Ticagrelor
ADP inhibitor
Half life of apixaban
12 hours
Mechanism of action of Rivaroxaban
Direct IXa inhibitor
These antiplatelet inhibit platelet aggregation by inhibiting ADP pathway of platelet
Ticlopidine and Clopidogrel
Mechanism of action of cilostazol
Phosphodiesterase inhibitor
Half life of Dabigatran
12-17 hours
Mechanism of warfarin
Block carboxylation of glutamate residue in: Prothrombin, F VII, IX and X and protein C/S
Inhibit vitamin K epoxidase reductase
What is the mechanism of action of Dypriridamole
Inhibit adenosine uptake and cGMP phosphodiesterase activity
Mechanism of action of Dabigatran
Direct thrombin inhibitor
What blood parameter dabigatran increases
PTT
Activity of heparin depends on the endogenous anticoagulant ____________
Antithrombin
Anithrombin inhibits the following:
Clotting factor proteases
IIa
IXa
Xa
Pharmacodynamic mechanism of VKA
- Synergism - impaired hemostasis and reduced clotting factors
- Competitive antagonism - Vit K
- Alteration of physiologic loop for VKA
Half life of warfarin
36 hours
Mechanism of action of Apixaban
Direct IXa inhibitor
This is a monoclonal antibody against IIb/IIIa complex
Abciximab
What medication increases level of rivaroxaban
Ketoconazole
Reversal of Heparin
Protamine Sulfate
Drug interaction of VKA
Inducer of CYP2CA
BDZ and RIfampicin - decreases the anticoagulant activty
Cholestyramine - binds to VKA and reduces absorption
What is the mechanism of action of ASA
Inhibit the synthesis of thromboxane A2 by irreversible acetylation of enzyme COX
Toxicity of heparin
Bleeding
Alopecia
Heparin Induced thrombocytopenia
Reversal agents for VKA
Vit K1
FFP
rFVIIa
Maintenance dose of VKA
5-7mg/d