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Neuropharma > Anti-parkinsonism > Flashcards

Anti-parkinsonism Flashcards

1
Q

This drug should not be given with MAO inhibitor as this may result to

A

Hypertensive crisis

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2
Q

What drug should not be given with apomorphine that it may precipitate hypotension

A

5-HT3 antagonist

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3
Q

Cardiac valvulopathy is observed in patient on this medication

A

Pergolide

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4
Q

Drugs that induced parkinsonism

A

Reserpine - depletes monoamine storage

Haloperidol - blocks dopa receptor

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5
Q

Acts both centrally and peripherally COMT inhibitor

A

Tolcapone

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6
Q

Cardiovascular effect of L-Dopa

A

Tachycardia
Postural hypotension
Hypertension

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7
Q

What trial evaluate the neuroprotective benefit of MAO-inhibitors

A

ADAGIO

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8
Q

Most common side effect of L-dopa

A

Anorexia, nausea and vomiting

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9
Q

Peripheral COMT-inhibitor

A

Entacapone

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10
Q

This is more potent in MPTP induced parkinsonism

A

Rasagaline

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11
Q

What exacerbates the GI adverse effect of L-dopa and should be avoided

A

Phenothiazine

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12
Q

Ergot derivatives stimulates both D1 and D2

A

Pergolide

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13
Q

Elimination of Pramipexole is thru

A

Renal

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14
Q

Mechanism of action of Pramipexole

A
  1. D3 agonist
  2. scavenge hydrogen peroxide
  3. enhance neutrophic activity in mesencephalic dopaminergic cell culture
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15
Q

Adverse effect of Entacapone and Tolcapone

A

orange discolioration of urine
Dyskinesia
nausea
elevated live enzymes (tolcapone)

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16
Q

Peak plasma concentration of Levodopa

A

1-2 hours

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17
Q

Contraindication for L-DOpa

A
  1. Known psychotic patients
  2. Angle-Closure glaucoma
  3. Bleeding gastric ulcer
  4. Active malignant melanoma
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18
Q

Levodopa effects usually diminishes after how many years

A

3-4 years

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19
Q

Contraindication in using ergot derivatives

A

Peripheral vascular disease

20
Q

Reason for L-dopa non-responders

A

Loss of dopaminergic nigostriatal nerve terminals

21
Q

This drug may cause digital vasospasm

A

Bromocriptine

22
Q

What are the 3 drugs combination of Stalevo

A

Levodopa, carbodpa and entacapone

23
Q

This is a non-ergot derivatives that has preferential affinity rto D3 family receptors

A

Pramipexole

24
Q

half life of amantadine

A

2-4 hours

25
Q

What is the mechanism of behavioral effects of L-Dopa

A

Common in patient on carbidopa because higher level reach the brain

26
Q

D2 agonist

A

Bromocriptine

27
Q

Adverse effects of Amantadine

A 
Livedoreticularis
Peripheral eddema
Restlessness
Hallucination
Caurtion in patient with hepatic and seizure
28
Q

Pergolide is not being used because of this

A

Development of valvular heart disease

29
Q

Mechanism of action of Apomorphione

A

Non-ergonaline Dopa agonist in postsynaptic D2 receptor in caudate and putamen

30
Q

Half-life of levodopa

A

1-3 hours

31
Q

What is the mechanism of Ropinirole

A

Pure D2 receptor agonist

32
Q

Mechanism of action of Amantadine

A
  1. Potentiate dopaminergic function by influencing synthesis, release or reuptake of dopamine
  2. Antagonize A-2A receptor that inhibit D2 receptor function
33
Q

Mechanism of action of Selegeline

A

irreversible MAO-B inhibitor

34
Q

What medication improves tremor and rigidity

A

Anti muscarinic

Benztropine, biperiden, trihexyphenidyl

35
Q

This medication reduces the amplitude of tremor

A

Propanolol

36
Q

May result with Serotonin syndrome if given with the following drugs

A

SSRI and TCA

37
Q

How is Ropinirole metabolize

A

CYP1A2

38
Q

This is a skin patch that is a dopamine agonist

A

Rotigotine

39
Q

Reason fro GI upset with L-Dopa

A

Stimulation of CTZ

40
Q

This drug depletes cerebral dopa and reduces the severity of chorea in HD

A

Tetrabenzine

41
Q

Mechanism of action of COMT inhibitors

A

Prolong action of L-dopa by diminishinh peripheral metabolism

42
Q

Erythromyelgia can be seen in this dopa agonist

A

Pramipexole and ropinirole

43
Q

Product of excretion of Dopamine are

A

HVA and Dihydroxyphenelyacetic acid

44
Q

What medication enhances the extracerebral metabolism of L-Dopa

A

Vitamin B6

45
Q

Duration of effect of apomorphine

A

10mins to 2 hours

Neuropharma (6 decks)

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