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Anti-psychotics Flashcards

1
Q

Blocking of D2 receptor is strongly related to

A

EPS

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2
Q

Drug interaction of Lithium

A

Decrease clearance if given with thiazide and prostaglandin

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3
Q

Dopamine receptor that is found in the cortex only

A

Dopamine 4

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4
Q

Example of Aliphatic Phenothiazine

A

Chlorpromazine

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5
Q

Receptor affinity of Haloperidol

A

D2 > Alpha-1

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6
Q

What is the mechanism of action of lithium (2)

A
  1. suppresses inositol signal thru depletion of intracellular inositol
  2. Inhibit glycogen synthase kinase (GSK-3)
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7
Q

What antipsychotic that causes retinal deposition resembling retinitis pigmentosa

A

Thioridazine

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8
Q

What is the mechanism of developing neuroleptic malignant syndrome

A

Excess rapid blockade of postsynaptic dopamine receptor

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9
Q

Antipsychotic drug than can cause seizure

A

Chlorpromazine

Clozapine

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10
Q

Receptor affinity of Quetiapine

A

H1>Alpha1>M1>D2>5HT2A

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11
Q

Akathisia and Dystonia can be ameliorated by

A

Diphenhydramine

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12
Q

Aggranulocytosis occurs in this antipsychotic medication

A

Clozapine (6-8th week)

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13
Q

This antipsychotic causes DM and gain weight

A

Clozapine and olanzapine

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14
Q

If parkinsonism arise secondary from antipsychotic medication what can be given?

A

Antiparkinsonism of antimuscarinic type

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15
Q

What class of antipsychotics causes Prolongation of QT interval

A

Ziprasidone

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16
Q

What medication causes anterior deposits in the eye

A

Chlorpromazine

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17
Q

This medication has both D2 and 5HT2A antagonist and has greater effect as negative symptoms of schizophrenia

A

Caprizapine

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18
Q

Receptor affinity of Chlorpromazine

A

Alpha1=5HT2A>D2

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19
Q

Adverse effect of lithium

A 
Tremor
Subclinical hypothyroidism
Nephrogenic DI  - low response to ADH
Edema
Sick sinu syndrome
Acneiform eruption
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20
Q

Among the atypical antipsychotic, which is the least can cause weight gain

A

Ziprasidone

21
Q

Receptor affinity of Clozapine

A

D4=Alpha1>5HT2A

22
Q

How does VPA works in Bipolar

A

Indirectly inhibit GSK-3 causes upregulation thru inhibition of histone deacetylase
Inhibits inositol depletion mechanism

23
Q

Atypical antipsychotics alter what NT

24
Q

This antipsychotic may cause T-wave changes, torsades and cardiac conduction blocks

A

Thioridazine

25
Q

Dopamine receptor that decreases CAMP

A

Dopamine 3 4 and 5

26
Q

Glutamate receptor

A

Group I - mGlur 1 and 5
Group 2 - mGlur 2 and 3
Group 3 - mGlur 4678

27
Q

Reason for polyuria and subclinical hypothyroidism in lithoum

A

Uncoupling of receptor from G protein (vasopressin and TSH)

28
Q

What is the mechanism of tardive dyskinesia induced by antipsychotics

A

Due to supersensitivity of dopamine receptor in the caudate and putamen

29
Q

Chromosome involved in Bipolar Disorder

A

8p and 13q

30
Q

Mechanism of action of Aripriprazole

A
  1. Partial D2 receptor agonist

2. Partial agonist of 5HT2A and 1A

31
Q

Plasma concentration of lithium

A

0.6-1.4meg/L

32
Q

This atypical antipsychotic produces elevation of prolactine

A

Risperidone

33
Q

Volume of distribution of lithium

34
Q

Dopamine receptor where typical antipsychotics medication takes place

35
Q

Receptor affinity of Olanzapine

36
Q

Describe D1 receptor

A

Chromosome 5

Increases CAMP

37
Q

Affinity of Thioxanthene

A

very high D2 / 5-HT2A rational

38
Q

maintenance level of lithium

A

0.6-0.9meq/L

39
Q

Effect of lithium on second messenger

A
  1. inhibit IMPase -> fail conversion of inositol

2, Uncouple G protein

40
Q

Treatment for neuroleptic malignant syndrome

A

Muscle relaxant
BDZ
Dantrolene
Bromocriptine

41
Q

This antipsychotic causes Myocarditis

42
Q

This drug has equal potency for D2 and D3 but antagonist to 5HT 7

43
Q

Example of Thioxantene

A

Thiothioxene

44
Q

These class of antipsychotic causes orthostatic hypotension, tachycardia

A

Phenothiazine

45
Q

Example of Butyrophenone

A

Haloperidol

46
Q

This antipsychotic reduces the risk of suicide

47
Q

2 Types of Phenothiazine derivatives

A
  1. Aliphatic

2. Piperidine

48
Q

Orthostatic hypotension and impaired ejaculation are the adverse effect of what antipsychotic

A

Chlorpromazine

Neuropharma (6 decks)

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