Antiretroviral Therapy Flashcards
What are the nucleoside reverse transcriptase inhibitors?
abacavir, emtricitabine, lamivudine, tenofovir disoproxil fumarate, tenofovir alafenamide, zidovudine
What are the adverse events of abacavir?
hypersensitivity reaction
What are the adverse events of tenofovir disoproxil fumarate?
renal insufficiency
osteomalacia
What are the adverse effects of zidovudine?
bone marrow suppression
What are the non-nucleoside reverse transcriptase inhibitors?
efavirenz, nevirapine, etravirine, rilpivirine, doravirine
What are the adverse effects of efavirenz?
CNS (somnolence, abnormal dreams, suicidality)
What are the protease inhibitors?
atazanavir, darunavir, fosamprenavir, lopinavir/ritonavir, nelfinavir, ritonavir, tipranavir
What are the adverse effects of atazanavir?
indirect hyperalbuminemia
What are the adverse effects of ritonavir?
N/V/D
What is the pharmacokinetic enhancer?
cobicistat
What are the adverse effects of cobicistat?
increased serum creatinine
What are the integrase strand transfer inhibitors?
raltegravir, elvitegravir, dolutegravir, bictegravir, cabotegravir
What are the adverse effects of raltegravir?
CK elevations
What are the entry inhibitors?
attachment inhibitor: fostemsavir
post-attachment inhibitor: ibalizumab
chemokine coreceptor 5 antagonist: maraviroc
What is the capsid inhibitor?
lenacapavir
