Antiretroviral Drug

Question 1

What are the anti retro viral drugs

Answer 1

Nucleoside reverse transcript is non nucleoside reverse transcript is protease inhibitor entry inhibitor integers inhibitor

Question 2

The mechanism of nucleoside reverse transcriptase

Answer 2

These drugs after entering HIV infected cells are converted to the active fry phosphate form by cellular kines and competitively inhibit the HIV river transcript is which will interrupt the growing viral DNA and terminate the chain elongation of pro viral DNA

Question 3

Which drugs are included in nucleoside reverse transcript is inhibitor

Answer 3

Zidovudine
Stavudine
Lamivadine
Emtricitabine
Abacavir
Didanasone

Question 4

Characteristics of nRTI

Answer 4

Effective against HIV 1 and hiv2

Protects any uninfected cell

Question 5

Which thymidine analogue is used as nucleoside reverse transcript is inhibitors

Answer 5

Zidovudine
Protype drug of nRTI
Protects uninfected cell
Cross placental barrier

Question 6

Adverse drug reaction of zidovudine

Answer 6

Bone marrow suppression
Anemia
Neutropenia
Initially....
Nausea
Vomitting
Long term therapy
  Hepatotoxicity
   Myopathy with fatigue

Question 7

Which nucleoside reverse transcriptase inhibitor cause hypersensitivity reaction

Answer 7

Abacavir

Question 8

Which nucleoside reverse transcriptase inhibitor is effective against hepatitis b virus

Answer 8

Tenofovir

Question 9

Non nucleoside reverse transcriptase inhibitor

Answer 9

Effective against HIV 1
Directly and noncompatitively inhibits HIV riverse transcriptase
enzyme
Can be combined with nRTI for the treatment of aids

Question 10

Which drugs are included in non nucleoside reverse transcriptase inhibitors

Answer 10

Nevirapine
Delaviridine
Efavirenz

Question 11

What are the adverse reaction of non nucleoside reverse transcript is inhibitor

Answer 11

Skin rashes, fever ,nausea, CNS disturbences

Question 12

Nevirapine information

Answer 12

Highly lipids soluble
Cross placental barrier
ADR rashes, hepatotoxicity

Question 13

Which non nucleoside reverse transcript is drug has longer duration of action

Answer 13

Efivarinz

Question 14

Which are the drugs which are included in protease inhibitors

Answer 14

Idinavir
Nelfavir
Ritonavir

Question 15

Mechanism of action of protease inhibitor

Answer 15

It competitively in he beat HIV protest enzyme and prevent cleavage of polyproteins to final functional structure enzymetic component of HIV which will infect the other cell and so the infection of other cell is prevented

Question 16

Adverse drug reaction of protease inhibitor

Answer 16

Nausea ,vomiting ,diarrhoea ,muscle wasting, insulin resistance ,diabetes

Question 17

Which protease is inhibitor inhibits both HIV 1 and hiv2

Answer 17

Ritonavir

Question 18

Example of entry fusion inhibitor

Answer 18

Enfuvirtide

Maraviroc

Question 19

Ccr5 chemokine receptor antagonist

Answer 19

Maraviroc

Question 20

Side effects of entry fusion inhibitor

Answer 20

Pain

Erythema

Question 21

Example of integrase inhibitor

Answer 21

Raultegravir

Dolutegravir

Question 22

Mechanism of action of integerase inhibitor

Answer 22

The prevent integration of viral DNA with the host DNA and are effective against both HIV 1 and hiv2

Question 23

Prophylaxis of HIV infection

Answer 23

1.pre exposure prophylaxis
High risk - heterosexual men, transgender,iv drug abuser
FDC- tenofovir (300mg)+emtricitabine (200mg)
2.post exposure prophylaxis
Initiated within 72 hours of exposure
Same fdc
Drug administration till 28 days