Antiretroviral Drug Flashcards
What are the anti retro viral drugs
Nucleoside reverse transcript is non nucleoside reverse transcript is protease inhibitor entry inhibitor integers inhibitor
The mechanism of nucleoside reverse transcriptase
These drugs after entering HIV infected cells are converted to the active fry phosphate form by cellular kines and competitively inhibit the HIV river transcript is which will interrupt the growing viral DNA and terminate the chain elongation of pro viral DNA
Which drugs are included in nucleoside reverse transcript is inhibitor
Zidovudine Stavudine Lamivadine Emtricitabine Abacavir Didanasone
Characteristics of nRTI
Effective against HIV 1 and hiv2
Protects any uninfected cell
Which thymidine analogue is used as nucleoside reverse transcript is inhibitors
Zidovudine
Protype drug of nRTI
Protects uninfected cell
Cross placental barrier
Adverse drug reaction of zidovudine
Bone marrow suppression Anemia Neutropenia Initially.... Nausea Vomitting Long term therapy Hepatotoxicity Myopathy with fatigue
Which nucleoside reverse transcriptase inhibitor cause hypersensitivity reaction
Abacavir
Which nucleoside reverse transcriptase inhibitor is effective against hepatitis b virus
Tenofovir
Non nucleoside reverse transcriptase inhibitor
Effective against HIV 1
Directly and noncompatitively inhibits HIV riverse transcriptase
enzyme
Can be combined with nRTI for the treatment of aids
Which drugs are included in non nucleoside reverse transcriptase inhibitors
Nevirapine
Delaviridine
Efavirenz
What are the adverse reaction of non nucleoside reverse transcript is inhibitor
Skin rashes, fever ,nausea, CNS disturbences
Nevirapine information
Highly lipids soluble
Cross placental barrier
ADR rashes, hepatotoxicity
Which non nucleoside reverse transcript is drug has longer duration of action
Efivarinz
Which are the drugs which are included in protease inhibitors
Idinavir
Nelfavir
Ritonavir
Mechanism of action of protease inhibitor
It competitively in he beat HIV protest enzyme and prevent cleavage of polyproteins to final functional structure enzymetic component of HIV which will infect the other cell and so the infection of other cell is prevented
Adverse drug reaction of protease inhibitor
Nausea ,vomiting ,diarrhoea ,muscle wasting, insulin resistance ,diabetes
Which protease is inhibitor inhibits both HIV 1 and hiv2
Ritonavir
Example of entry fusion inhibitor
Enfuvirtide
Maraviroc
Ccr5 chemokine receptor antagonist
Maraviroc
Side effects of entry fusion inhibitor
Pain
Erythema
Example of integrase inhibitor
Raultegravir
Dolutegravir
Mechanism of action of integerase inhibitor
The prevent integration of viral DNA with the host DNA and are effective against both HIV 1 and hiv2
Prophylaxis of HIV infection
1.pre exposure prophylaxis
High risk - heterosexual men, transgender,iv drug abuser
FDC- tenofovir (300mg)+emtricitabine (200mg)
2.post exposure prophylaxis
Initiated within 72 hours of exposure
Same fdc
Drug administration till 28 days
