Antileprotic Drug Flashcards
What is leprosy
Leprosy is a chronic infectious disease caused by mycobacterium lapray which is an acid fast Bacilli
What are the type of leprosy
Lepromatous leprosy
Cell mediated immunity is impaired
Course disease progress rapidly
Extensive bilateral skin lesions which contain numerous laprabacilli and involvement of more than one nerve
Tuberculoid leprosy
Cell mediated immunity is intact and predominant peripheral nerve involvement with single skin lesions
Bacilli are really seen
Which are antileprotic drugs
Rifampicin
Dapsone
Clofazi mine
Ethionamide
Which sulphone is widely used as antileprotic drug
Dapsone
Mechanism of action of dapsone
Paramino benzoic acid is converted into tetrahydropolic acid with the help of enzyme folate synthase which is inhibited by dapsone ….which will kill the bacilli
Adverse drug reaction of dapsone
Hemolysis in g6pd deficiency
Conc in infected skin, muscle,liver, kidney
Peripheral neuropathy
Neuripsycatric side effects
What is sulphone syndrome
Dapsone may cause excerbation of lesions
Uses of dapsone
Leprosy
Malaria
Dermatitis
Prophylaxis of pneumocystitis and toxoplasmosis
What is the chemotherapy of leprosy
Multibacillary
the treatment is for 12 months the drug used are rifampicin,dapsone,clofazimine
Paucibacillary
treatment is for 6 months and the drug used are rifampicin and dapsone
What is Lepra reaction
Reversal reaction and erythema nodusum laparosum
What is reverse reaction
It is a delayed type of hypersensitivity reaction which is seen in multi and passive bacillary cases
Signs of inflammation in existing regions they become red warm and swollen
Nerve affected tender and painful
Treated with clofazi mine prednisolone
What is erythema nodusum laparosum
It occurs in laprimetas leprosy
It is third type of hypersensitivity reaction due to release of antigen from dyeing laprabacilli
It is red painful tender cutaneous and subcutaneous nodule
Treated with thalidomide contraindicated in pregnancy
Describe clofazamine
It is a phenzine dye
Laprostatic activity and anti inflammatory effect
Mechanism of action of clofazi mine
It binds to myobacterium DNA to inhibit its template function
Uses of clofazimane
Treatment of leprosy first line
Second line for treatment of tuberculosis
