Anti Tubercular Drugs

Question 1

Which are the first line anti tubercular drugs?

Answer 1

Isoniazid
Rifampicin
pyrizinamide
Ethambutol
Streptomycin

Question 2

Which drug is given to the patient first to make him non infectious?

Answer 2

Isoniazid

Question 3

what Are the uses of isoniazid?

Answer 3

1st line drug

Chemo prophylaxis

Question 4

Mechanism of action of isoniazid

Answer 4

Inhibition of mycolic acid

Prodrug to active form

Question 5

Side effects of isoniazid

Answer 5

C change in memory
H hallucination
A anemia
N neuropathy
G gynecomastia
E euphoria

Question 6

Write the toxicity of isoniazid

Answer 6

Metabolic acidosis

Seizure

Question 7

Name the drug of choice in seizures caused by isoniazid

Answer 7

Pyridoxine

Max dose 5g

Question 8

Drug is able to cross the placenta barrier

Answer 8

Isoniazid

Question 9

Safest anti tubercular drug in renal failure

Answer 9

Rifampicin

Question 10

Bactericidal drug for antituberculosis

Answer 10

Rifampicin

Question 11

Mechanism of action of rifampicin

Answer 11

Binds to bacterial DNA dependent RNA polymerase and inhibit RNA synthesis

Question 12

Pharmaco kinetics of rifampicin

Answer 12

Rapidly absorbed by gi tract

Presence of food decreases the absorption

Question 13

Uses of rifampicin

Answer 13

Tb
Leprosy
Non tubercular mycobacterium
Add on to penicillin /vancomycin in staphylococcus infection
Add on to doxycycline in isoniazid may be used by doubling the dose

Question 14

adverse Drug reaction of rifampicin

Answer 14

R rash
I intestinal nephritis
F flu like symptoms
A anemia
M make urine secretion radish orange
P thrombocytopenia and pulmonary syndrome
I inducer of enzyme
C contraceptive failure
I inr can be derranged
N nevirapine failure change to efavirenz

Question 15

which Is the most hepatotoxic antiTB drug

Answer 15

Pyrizinamide

Question 16

Mechanism of action of Pyrizinamide

Answer 16

Pro drug converted to pyrazinoic acid which blocks the fatty acid synthase one

Question 17

Which anti tubercular drug is distributed all over including CSF

Answer 17

Pirazinamide

Question 18

Side effects of pyrazinamide

Answer 18

P peripheral neuropathy
A athralgia
H hepatotoxic
H hyperuricemia

Question 19

Which antitubercular drug is the most unsafe in renal failure

Answer 19

Ethambutol

Question 20

Mechanism of action of ethambutol

Answer 20

Blocks synthesis of arabinosyl transferase and decrease synthesis of arabinogalacton

Question 21

Uses of ethambutol

Answer 21

MTB and MAC

Question 22

Adverse drug reaction of ethambutol

Answer 22

Optic neuritis and red green colour blindness
Toxicity to eye prevented by vitamin b12
Hyperuriceamia
Safe in pregnancy

Question 23

Which antitubercular drug is contraindicated in children and is safe in pregnancy

Answer 23

Ethambutol

Question 24

Which amino glycoside antibiotic is used in anti tuberculosis drug

Answer 24

Streptomycin

Question 25

What is the dosage form of streptomycin and what are the adverse drug reaction

Answer 25

Injection -im
Ototoxicity
Nephro toxicity
Neuromuscular blockage

Question 26

What is the treatment phase of tuberculosis

Answer 26

Intensive phase
Patient receive treatment with 4 to 6 drugs daily for a period of 2 months. main objective of this phase is to rapidly kill the Bacilli and make the patient non contagious
Continuous phase
Patient receive 3 to 4 drug daily for a period of 4 month this phase helps to eliminate the remaining Bacilli and prevent relapse