Antipyretics MEDICATION-SIDE EFFECTS

Question 1

GI- gastritis, dyspepsia, ulcers, bleeding

Renal impairment

Allergy

Answer 1

Aspirin

Question 2

GI- gastritis, dyspepsia, ulcers, bleeding

( selective cox 2 inhibitors are known to cause an increase risk of thrombotic events like MI and stroke

Ex. Celecoxib (Celebrex)

Answer 2

Ibuprofen

Question 3

Few liver toxicity in high doses, regular doses

Answer 3

Acetaminophen

Question 4

Allergy,

GI- diarrhea, dyspepsia

Renal impairment can cause penicillins to accumulate to toxic levels

Suprainfections possible

Answer 4

Ampicillin

Question 5

Allergy,

GI- diarrhea, dyspepsia

Renal impairment can cause penicillins to accumulate to toxic levels

Suprainfections possible

Answer 5

Augmentin

Question 6

Risk of increased bleeding with warfarin because of interference with vitamin k metabolism

Allergy

GI upset: diarrhea and pseudo membranous colitis

Immune-related hemolytic anemia

Can promote clostidrium difficile super-infection

Answer 6

Cefazolin

Question 7

Ototoxic and nephrotoxic

Adjust for renal impairment

Answer 7

Gentamycin

Question 8

Can cause tendon rupture or tendonitis

Photosensitivity

Candida suprainfections, especially of the oropharynx

Infrequent but serious cns effects

Answer 8

Cifrolaxacin (Cipro)

Question 9

Discoloration of developing teeth

GI distress (epigastric burning, cramps, nausea, vomiting, diárrhea)

Photosensitivity

Candidiasis

Answer 9

‘tetracycline

Question 10

Hypersensitivity reactions are most concerning:

Rash, including rare steven-johnson syndrome

Heme:hemolytic anemia and other blood dyscrasias (agranulocytosis leukopenia, thrombocytopenia, aplastic anemia)

Crystalluria- kidney stones, bladder stones

CNS- headache, psychosis

Answer 10

Trimethroprim-sulfamethoxazole (TMP-SMZ)

Bactrim

Question 11

IV erythromycin and azithromycin are corrosive to veins.

Some forms of erythromycin are corrosive to GI tract and can cause erosive esophagitis

Answer 11

Erythromycin

Question 12

Ototoxicity and dose-related nephrotoxicity

Multiple drug interactions with hyperlipidemic drugs,muste relaxants and ototoxic drugs

Irritating to the vein causing thrombophlebitis (use large vein and change site often

Rapid infusion can cause “red man syndrome”

Answer 12

Vancomycin

Question 13

Cytochrome p450 interactions

Darkening of urine

CNS e adverse effects

Caution during pregnancy during lactation

Answer 13

Metronidazole (flagyl)