Antipyretics MEDICATION-ACTION

Question 1

Irreversible nonselective inhibitor of COX 1 and 2
Anti inflammatory
Antipyretic

Answer 1

Aspirin

Question 2

Nonselective inhibitor of COX 1 and 2, but more selective of COX 1

Blocks prostaglandin synthesis and modulates T-cell production

Anti inflammatory

Antipyretic

Answer 2

Ibuprofen (motrin, advil)

Question 3

Decreases prostaglandin synthesis in the CNS (NO anti inflammatory effect peripherally)

Answer 3

Acetaminophen

Question 4

Affects cell wall synthesis

Answer 4

Ampicillin

Question 5

Affects cell wall synthesis

Answer 5

Augmentin

Question 6

Affects cell wall synthesis

Answer 6

Cefazolin

Question 7

Penetrate cell wall of susceptible bacteria and bind irreversibly to 30s and 50 S ribosomal subunits- intracellular structures that synthesize proteins

When given IV, widely distributed

Poorly absorbed systematically in the GI tract; so can act locally in the GI tract

Answer 7

Gentamycin

Question 8

Inhibit an enzyme (dna gyrase) important in bacterial dna replication

Answer 8

Cifrofloxin (cipro)

Question 9

Bind to 30 s ribosomal subunit

Broad spectrum but resistance has developed

Answer 9

Tetracycline

Question 10

Blocks bacterial enzymes that are important for the synthesis of the building blocks of dna. Rna, and proteins

Combination of a sulfa drug (sulfamethoxazole) and an inhibitor of a bacterial enzyme called dihydrofolate reductase ( trimethroprim)- are synergistic in their activity

Answer 10

Trimethroprim- sulfamethoxazole (TMP-SMZ)

bactrim

Question 11

Inhibit 50s ribosomal subunit

Answer 11

Erythromycin

Question 12

Affects cell wall synthesis

Answer 12

Vancomycin

Question 13

A prodrug that is activated only in anaerobic cells

Answer 13

Metronidazole (flagyl)