Antipsychotics - Essential Drugs for Exam 1

Question 1

Amisulpiride (Solian)

Answer 1

2nd Generation; low diabetogenic effects

Question 2

Ziprasidone (Geodon)

Answer 2

2nd Generation; anxiolytic + antidepressant actions; low weight gain

Question 3

Quetiapine (Seroquel)

Answer 3

2nd Generation; abused more frequently than other antipsychotics

Question 4

Sertindole (Serlect)

Answer 4

2nd Generation; doesn’t bind to histamine (H) receptors, so no sedative effects

Question 5

Olanzapine (Zyprexa)

Answer 5

2nd Generation; improves negative symptoms of schizophrenia

Question 6

Clozapine (Clozaril)

Answer 6

2nd Generation; first model of antipsychotics; increased risk of agranulocytosis

Question 7

Aripiprazole (Abilify)

Answer 7

“3rd Generation;”
* improves positive/negative symptoms of schizophrenia
* less side effects (extrapyramidal symptoms/tardive dyskinesia, weight gain, lipid abnormalities, hyperprolactinemia)
* strong efficacy + strong side effect profile (prevents future relapses)

Question 8

Cariprazine (Vraylar)

Answer 8

2nd Generation;
* used for schizophrenia, bipolar I, maybe for major depressive disorder
* higher potency to D3 receptor compared to other drugs
* higher affinity to D3 > D2 receptor
* well-tolerated amongst disorders and special populations

Question 9

Paliperidone (Invega)

Answer 9

2nd Generation;
* difficult to use/tolerate, especially when used with other medications
* requires patience to those who are averse in taking Invega (multiple unpleasant side effects)
* not much research in its mechanism

Question 10

Xanomeline (Trospium)

Answer 10

2nd Generation;
* Less serious/strenuous side effects compared to other drugs
* Needs more information (new drug)
* Strong potential to improve cognition in those with neurodegenerative diseases