antipsychotics

Question 1

What is the MOA of first generation antipsychotics?

Answer 1

D2 receptor antacongists

Question 2

What is the MAO of second generation antipsychotics?

Answer 2

D2 and 5-HT2 receptor antagonists

Question 3

How do trazodone and mirtazapine work?

Answer 3

5-HT2 antagonists

Question 4

What are the advantages of buspirone?

Answer 4

• not sedating
• not addictive
• has 5-HT1A agonist properties and may be used to boost anti-depressant properties

Question 5

What is prazosin

Answer 5

• aka minipress
• alpha antagonist
• used to treat nightmares of PTSD

Question 6

What drugs can be used to treat PTSD nightmares?

Answer 6

• prazosin (alpha antagonist); aka minipress

- clonidine or guanfacin (alpha 2 agonists)

Question 7

What drugs can be used to treat PTSD nightmares?

Answer 7

• prazosin (alpha antagonist); aka minipress

- clonidine or guanfacin (alpha 2 agonists)

Question 8

What drugs are used for alcohol dependence?

Answer 8

1. disulfram (causes bad rxn to EtOH consumption by blocking acetaldehyde dehydrogenase)
2. naltrexone- reduces reward of alcohol consumption by blocking opioid receptors
3. Acamprosate- reduces craving that occurs from increased glutamate during abstinence