Antipsychotics Flashcards
Psychotic sxs are results of what?
Excess DA and 5HT
Positive sxs are results of which receptor activation?
Which pathway?
DA D2
Mesolimbic
Negative sxs are results of which receptor activation?
Which pathway?
5HT
Mesocortical
Which meds are Classic Antipsych?
Chlorpromazine/Thorazine
Prochlorperazine/Compazine
Fluphenazine/Prolixin
Haloperidol
Classic Antipsych affect which psychotic sxs?
Positive
Which meds are Atypical Antipsych?
Clozapine/Clozaril Olanzapine/Zyprexa Quetiapine/Seroquel Aripiprazole/Abilify Risperidone Ziprisadone/Geodon
Atypicals affect which psychotic sxs?
Positive and negative
Antipsych s/e?
Sleepy Wgt gain Long QTI Hyperprolactinemia Antichol effects Akathisia (restless/anxious) Dystonia (mm spams, sustained posture) Parkinsonian (rigidity, delayed mvmt initiation) Tardive dyskinesia (uncontrolled mvmts) Decreased SEIZURE threshold
What is Neuroleptic Malignant Syndrome?
s/e of anti psych meds LIFE THREATENING mm rigidity/catatonia Inc body temp BP and HR changes
Neuroleptic Malignant Syndrome treatment?
Dantrolene (mm relax) + diazepam + bromocriptine (DA agonist)
Clozapine bad s/e?
Agranulocytosis
Benefits of aripiprazole?
No inc prolactin
No long QTI
Aripiprazole unique s/e?
Inc glucose
DOC for psychosis?
Risperidone
Ziprasidone used for?
Tourette’s
Acute mania