Antipsychotics Flashcards

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1
Q

Psychotic sxs are results of what?

A

Excess DA and 5HT

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2
Q

Positive sxs are results of which receptor activation?

Which pathway?

A

DA D2

Mesolimbic

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3
Q

Negative sxs are results of which receptor activation?

Which pathway?

A

5HT

Mesocortical

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4
Q

Which meds are Classic Antipsych?

A

Chlorpromazine/Thorazine
Prochlorperazine/Compazine
Fluphenazine/Prolixin
Haloperidol

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5
Q

Classic Antipsych affect which psychotic sxs?

A

Positive

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6
Q

Which meds are Atypical Antipsych?

A
Clozapine/Clozaril
Olanzapine/Zyprexa
Quetiapine/Seroquel
Aripiprazole/Abilify
Risperidone
Ziprisadone/Geodon
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7
Q

Atypicals affect which psychotic sxs?

A

Positive and negative

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8
Q

Antipsych s/e?

A
Sleepy
Wgt gain
Long QTI
Hyperprolactinemia
Antichol effects
Akathisia (restless/anxious)
Dystonia (mm spams, sustained posture)
Parkinsonian (rigidity, delayed mvmt initiation)
Tardive dyskinesia (uncontrolled mvmts)
Decreased SEIZURE threshold
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9
Q

What is Neuroleptic Malignant Syndrome?

A
s/e of anti psych meds
LIFE THREATENING
mm rigidity/catatonia
Inc body temp
BP and HR changes
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10
Q

Neuroleptic Malignant Syndrome treatment?

A

Dantrolene (mm relax) + diazepam + bromocriptine (DA agonist)

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11
Q

Clozapine bad s/e?

A

Agranulocytosis

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12
Q

Benefits of aripiprazole?

A

No inc prolactin

No long QTI

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13
Q

Aripiprazole unique s/e?

A

Inc glucose

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14
Q

DOC for psychosis?

A

Risperidone

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15
Q

Ziprasidone used for?

A

Tourette’s

Acute mania

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