Anticonvulsants Flashcards
GABA neurotrans roll in seizures?
GABAergic neuron activity controls seizures
Glutamate neurotrans roll in seizures?
Increase in Glutamate activity causes seizures
Sodium channels roll in seizures?
Open Na+ channels propagate APs
Rapid firing of Na+ channels leads to seizures
Calcium channels roll in seizures?
Absence seizures from overactive Ca+2 channels in thalamus
Drugs that increase GABA activity and decrease seizures?
Phenobarbital
BZs
Drugs that inhibit Glutamate transmission and decrease seizures?
Phenytoin/Dilantin Carbamazepine Lamotrigine Valporic acid Ethosuximide
Phenytoin/Dilantin inhibits metabolism of what drug?
Increases metabolism of what drugs?
What med increases metabolism of phenytoin?
Warfarin
OCP
Carbamazepine
Phenytoin/Dilantin s/e?
Gingival hyperplasia
Hirsuitism
Abn Vit D/Ca+2 absorb
Periph neuropathy
Carbamazepine/Tegretol uses?
Seizures
Bipolar
Trigem neuralgia
Carbamazepine/Tegretol s/e?
Diplopia
Ataxia
GI
AGRANULOCYTOSIS
Carbamazepine/Tegretol increases metabolism of what drugs?
What meds inhibit metabolism of Carbamazepine?
Phenytoin, valproic acid, OCP
Cimetidine, fluoxetine, EMC
Lamotrigine uses?
S/e?
Absence
Bipolar
Steven-johnson Dizzy HA N Somnolence
Gabapentin uses?
S/e?
Adjunct seizures
Neuropathic pain
Dizzy Drowsy Ataxia Wgt gain No preggos
Topiramate/Topamax s/e?
Dizzy
Sedation
Confusion
No preggos
Valproic Acid/Depakote uses?
S/e?
Seizures
Bipolar
N/V Tremor Wgt gain Hepatotoxicity Steve-John