Anticonvulsants Flashcards

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1
Q

GABA neurotrans roll in seizures?

A

GABAergic neuron activity controls seizures

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2
Q

Glutamate neurotrans roll in seizures?

A

Increase in Glutamate activity causes seizures

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3
Q

Sodium channels roll in seizures?

A

Open Na+ channels propagate APs

Rapid firing of Na+ channels leads to seizures

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4
Q

Calcium channels roll in seizures?

A

Absence seizures from overactive Ca+2 channels in thalamus

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5
Q

Drugs that increase GABA activity and decrease seizures?

A

Phenobarbital

BZs

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6
Q

Drugs that inhibit Glutamate transmission and decrease seizures?

A
Phenytoin/Dilantin
Carbamazepine
Lamotrigine
Valporic acid
Ethosuximide
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7
Q

Phenytoin/Dilantin inhibits metabolism of what drug?

Increases metabolism of what drugs?

What med increases metabolism of phenytoin?

A

Warfarin

OCP

Carbamazepine

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8
Q

Phenytoin/Dilantin s/e?

A

Gingival hyperplasia
Hirsuitism
Abn Vit D/Ca+2 absorb
Periph neuropathy

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9
Q

Carbamazepine/Tegretol uses?

A

Seizures
Bipolar
Trigem neuralgia

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10
Q

Carbamazepine/Tegretol s/e?

A

Diplopia
Ataxia
GI
AGRANULOCYTOSIS

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11
Q

Carbamazepine/Tegretol increases metabolism of what drugs?

What meds inhibit metabolism of Carbamazepine?

A

Phenytoin, valproic acid, OCP

Cimetidine, fluoxetine, EMC

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12
Q

Lamotrigine uses?

S/e?

A

Absence
Bipolar

Steven-johnson
Dizzy
HA
N
Somnolence
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13
Q

Gabapentin uses?

S/e?

A

Adjunct seizures
Neuropathic pain

Dizzy
Drowsy
Ataxia
Wgt gain
No preggos
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14
Q

Topiramate/Topamax s/e?

A

Dizzy
Sedation
Confusion
No preggos

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15
Q

Valproic Acid/Depakote uses?

S/e?

A

Seizures
Bipolar

N/V
Tremor
Wgt gain
Hepatotoxicity
Steve-John
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