Antidepressants Flashcards

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1
Q

TCA MOA?

A

Inhibit uptake: NE, 5HT

Block M, alpha, histamine receptors

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2
Q

TCA drug names? (4)

A

Amitriptyline
Imipramine
Nortriptyline
Desipramine

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3
Q

TCA common s/e? (7)

A
Sedation
Tachy/palp
Ortho hypoTN
Constipation
Urinary retention
Weight gain
Sex dysfxn
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4
Q

TCA bad s/e? (4)

A

Seizures
SIADH (hypoNa+)
Torsades in OD
Serotonin synd

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5
Q

TCA uses? (3)

A

Depression
Panic
Chronic pain/Fibro

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6
Q

SSRI drug names? (5)

A
Fluoxetine/Prozac
Paroxetine/Paxil
Sertraline/Zoloft
Citalopram/Celexa
Escitalopram/Lexapro
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7
Q

SSRI uses?

A
Depression (class is DOC)
Panic
OCD (Paxil DOC)
Social anxiety (Paxil DOC)
Bulimia
EtOH
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8
Q

SSRI s/e? (5)

A
N/D/C
Anxiety
Insomnia (flu, ser)
Sedation (pax)
Sex dysfxn
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9
Q

SSRI bad s/e? (3)

A
Serotonin synd (esp MAOI, St John's)
Drug interactions (anticonvulsants, warfarin, b-block)
SIADH
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10
Q

SNRI drug names? (3)

A

Venlafaxine/Effexor
Duloxetine/Cymbalta
Desvenlafaxine/Pristiq

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11
Q

SNRI uses? (5)

A
Depression
Panic/GAD/PTSD
DM neuro pain
Fibro
Hot flashes
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12
Q

SNRI s/e? (5)

A
Same as SSRI
Anorexia
Sweating
Dizziness
HTN
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13
Q

Duloxetine/Cymbalta contraindicated for who?

A

Narrow-angle glaucoma

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14
Q

Best SSRI for EtOHics?

A

Paxil (withstands reduced effectiveness caused by EtOH)

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15
Q

Bupropion MOA?

A

Inhib DA/NE re-uptake

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16
Q

Bupropion uses? (4)

A

Depression
Smoking cess
EtOHism
+SSRI to dec sex dysfxn

17
Q

Bupropion s/e? (3)

A

Wgt loss
Anxiety
Insomnia

18
Q

Bupropion bad s/e?

A

Seizures

Don’t use with antipsych or TCA

19
Q

Mirtazapine/Remeron MOA?

A

Inc release NE/5HT

20
Q

Mirtazapine benefits?

A
NO
SSRI s/e 
Anxiety
Insomnia
Sex dysfxn
21
Q

Mirtazapine s/e? (4)

A

Drowsiness
Dizziness
HA
Wgt gain

22
Q

Trazodone/Desyrel MOA?

A

5HT receptor antagonist

23
Q

Trazodone uses? (3)

A

Insomnia
Depression
Combatives

24
Q

Trazodone s/e? (3)

A

Ortho hypoTN
Dry mouth
N