antipsychotics

Question 1

Four DA tracts: effect of blocking each

Answer 1

Mesolimbic (clinical efficacy). Nigrostriatal (TD, parkinsonism, acute dystonias). Mesocrotical (worsens cognitive sx). Tuberoinfundibular (removes prolactin inhibition)

Question 2

efficacy of antipsychotic meds correlates to___. Potency correlates to___

Answer 2

degree of blockage of mesolimbic D2 receptors. affinity for mesolimbic D2 receptors

Question 3

Which has a greater efficacy than the rest

Answer 3

clozapine

Question 4

Neuroleptic malignant syndrome

Answer 4

from excess antipsychotics. FEVER: fever, encephalopathy, vitals unstable, elevated enzymes, rigidity. Tx by giving D2 agonist

Question 5

adverse effects related to DA blockade

Answer 5

Tardative dyskinesia, parkinsonism, hyperprolactinemia, AKATHESIA (inner restlessness)

Question 6

two of the three chemical structures and their drugs

Answer 6

phenothiazine nucleus: chlorpromazine, thioridazine, fluphenazine, perphenazine. Butyrophenones: halperidol

Question 7

Clozapine: what does it block? unique pros and cons

Answer 7

5HT and DA; greater efficacy, agranulocytosis

Question 8

benefit of SGAs over FGAs

Answer 8

fewer movement related SA due to additional 5HT blockade

Question 9

list the atypicals

Answer 9

clozapine, risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole

Question 10

name the FGAs

Answer 10

haloperidol + the “-azines”