Antipsychotics Flashcards
1
Q
1st generation antipsychotics
A
"zines" chlorpromazine thioridazine perphenazine pimozide thiothixene fluphenazine haloperidol (Haldol)
2
Q
1st gen MOA
A
strong antagonist to dopamine receptors
antagonist to muscarinic receptors for acetylcholine
3
Q
1st gen AE
A
extrapyramidal symptoms (EPS) amenorrhea gynecomastia anticholinergic effects low seizure threshold tachycardia orthostatic hypotension ejaculatory dysfunction
4
Q
What are extrapyramidal symptoms (EPS)?
A
dystonia akathisia dyskinesia tardive dyskinesia pseudoparkinsonism
5
Q
2nd gen (atypical) antipsychotics
A
“pines” and “dones”
clozapine (Clozaril) olanzapine (zyprexa) paliperidone (invega) quetiapine (seroquel) risperidone (risperdal) Aripiprazole (abilify) etc.....
6
Q
2nd gen atypical antipsychotic MOA
A
dopamine and serotonin antagonists
7
Q
2nd gen atypical antipsychotic AE
A
metabolic syndromes (weight gain, obesity, T2DM, HTN, HLD) sexual dysfunction cardiac conduction problems (prolonged QT)
8
Q
Clozapine specific NI
A
monitor WBCs for bone marrow suppression and agranulocytosis
9
Q
Risperdal specific NI
A
high risk for EPS and gynecomastia
10
Q
3rd gen atypical
A
aripiprazole (abilify)
paliperidone (invega)
11
Q
3rd gen MOA
A
dopamine and serotonin system stabilizer
12
Q
3rd gen AE
A
insomnia
akathisia
