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Psychopharmacology > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Tricyclic Antidepressants (TCAs)

A 
Amitriptyline (Elavil)
Nortriptyline (Pamelor)
Imipramine HCL (Tofranil)
Doxepin (Sinequan)
Trimipramine (Surmontil)
Clomipramine HCL (Anafranil)

The “in” and “ines”
all have “P”

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2
Q

TCA MOA

A

blocks reuptake of norepinephrine

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3
Q

TCA contra

A

glaucoma
MI
caution in patients with BPH

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4
Q

TCA AE

A 
Anticholinergic effects
Akathisia
Apathy
Anhedonia
Sedation
Orthostatic Hypotension
Cardiac arrhythmias
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5
Q

Selective Serotonin Reuptake Inhibitors (SSRIs)

A 
Fluoxetine (Prozac)
Sertraline (Zoloft)
Paroxetine (Paxil)
Citalopram HBr (Celexa)
Escitalopram (Lexapro)
Fluvoxamine (Luvox)
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6
Q

SSRI MOA

A

blocks the re-uptake and destruction of serotonin

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7
Q

SSRI AE

A 
Serotonin Syndrome
insomnia
agitation
N/V
weight changes
sexual dysfunction
bruxism
apathy
low libido
sedation
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8
Q

SSRI lethality

A

low!

difficult to overdose

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9
Q

Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

A 
Venlafaxine (Effexor)
Duloxetine (Cymbalta)
Desvenlafaxine (Pristiq)
Bupropion (Welbutrin)
Levomilnacipran (Fetzima)
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10
Q

SNRI MOA

A

increases serotonin, dopamine, and norepinephrine

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11
Q

SNRI use

A 
PTSD
OCD
GAD
Social anxiety
Panic disorder
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12
Q

Low dose of SNRI

A

blocks reuptake of serotonin

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13
Q

high dose of SNRI

A

blocks reuptake of norepinephrine

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14
Q

SNRI AE

A 
insomnia
agitation
headache
weight loss
sexual dysfunction
Serotonin Syndrome
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15
Q

Bupropion contra

A

seizure disorder
bulimia or anorexia
abrupt discontinuance of ETOH

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16
Q

Monoamine Oxidase Inhibitors (MAOIs)

A

Isocarboxazid (Marplan)
Phenelzine (Nardil)
Trancyclopromine (Parnate)
Selegiline

17
Q

MAOI MOA

A

inhibits the action of monoamine oxidase

18
Q

MAOI AE

A 
Hypertensive crisis with Tyramine
orthostatic hypotension
headache
anticholinergic effects
nystagmus
hypermetabolic syndrome
19
Q

MAOI NI

A 
Do not take with other antidepressants
avoid tyramine (in foods and cold/flu meds)
20
Q

Atypical Antidepressants

A 
Bupropion (Welbutrin)
Trazodone (Desryl)
Mirtazadone (Remeron)
Nefazodone (Serzone)
Amoxapine (Asedin)
Maprotiline HCL (Ludiomil)
Vortioxetine (Trintellix)
Vilazodone (Viibryd)
21
Q

Atypical antidepressants MOA

A

dopamine-norepinephrine reuptake inhibitor and also inhibits nicotine acetylcholine receptors

22
Q

Atypical Antidepressant AE

A

insomnia
tremors
anorexia
weight loss

23
Q

Trazadone specific AE

24
Q

Nefazodone specific AE

A

hepatic failure

Psychopharmacology (5 decks)

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