Antipsychotic medications

Question 1

Is Amisulpride (solian, solprix) a typical or atypical antipsychotic?

Answer 1

Atypical

Question 2

Is Aripiprazole (abilify) a typical or atypical antipsychotic?

Answer 2

Atypical

Question 3

Is Asenapine (Saphris) a typical or atypical antipsychotic?

Answer 3

Atypical

Question 4

Is Brexpriprazole (rexulti) a typical or atypical antipsychotic?

Answer 4

Atypical

Question 5

is Chlorpromazine (largactil) a typical or atypical antipsychotic?

Answer 5

Typical

Question 6

Is Clozapine (Clopine) a typical or atypical antipsychotic?

Answer 6

Atypical

Question 7

Is Flupentixol (bentovate) a typical or atypical antipsychotic?

Answer 7

Typical

Question 8

Is Haloperidol (serenace) a typical or atypical antipsychotic?

Answer 8

Typical

Question 9

Is Lurasidone (Ardix lurasidone, latuda, lurasidone lupin) a typical or atypical antipsychotic?

Answer 9

Atypical

Question 10

Is Olanzapine (pyrex) a typical or atypical antipsychotic?

Answer 10

Atypical

Question 11

Is Paliperidone (invega) a typical or atypical antipsychotic?

Answer 11

Atypical

Question 12

Is periciazine (neulactil) a typical or atypical antipsychotic?

Answer 12

Typical

Question 13

Is Quetiapine (seroquel, quetia, quepine, tevatiapine) a typical or atypical antipsychotic?

Answer 13

Atypical

Question 14

Is Risperidone (risperidal) a typical or atypical antipsychotic?

Answer 14

Atypical

Question 15

Is Ziprasidone (Ziprox, Zeldox) a typical or atypical antipsychotic?

Answer 15

Atypical

Question 16

Is Zuclopenthixol (clopixol) a typical or atypical antipsychotic?

Answer 16

Typical

Question 17

In schizophrenia, what is the oral dosage of Amisulpride (solian, solprix)?

Answer 17

100mg at night initially

Increasing to 200mg twice daily

Maximum dose is 1200mg per day

Question 18

In schizophrenia, what is the oral dosage of Aripiprazole (abilify)?

Answer 18

10mg once daily initially

Increase to 15mg once daily

Maximum dosage is 30mg per day

Question 19

In schizophrenia, what is the oral dosage of Olanzapine (pyrex)?

Answer 19

5mg at night initially

Increase to 10mg at night

Maximum dose is 30mg per day

Question 20

In schizophrenia, what is the oral dosage of Paliperidone (invega)?

Answer 20

3mg orally at night

Increase to 6mg at night

Maximum dose is 12mg per day

Adjust dose in renal impairment patients

Question 21

In schizophrenia, what is the oral dosage of Quetiapine (seroquel, quetia, quepine, tevatiapine)?

Answer 21

50mg twice daily on day 1

100mg twice daily on day 2

Increasing to 200mg twice daily (response usually seen in higher dosages)

Maximum dosage is 800mg per day

Question 22

In schizophrenia, what is the oral dosage of Risperidone (risperidal)?

Answer 22

0.5-1mg at night initially

Increase to 2mg at night

Maximum dose is 6mg

Question 23

In schizophrenia, what is the oral dosage of Ziprasidone (Ziprox, Zeldox)?

Answer 23

40mg twice daily with food

Maximum dosage 80mg

Question 24

In schizophrenia, what is the oral dosage of Asenapine (Saphris)?

Answer 24

5mg sublingually twice per day, before food.

Maximum dosage is 10mg

Question 25

In schizophrenia, what is the oral dosage of Chlorpromazine (largactil)?

Answer 25

200mg at night initially Staged increase to maximum of 800mg

Question 26

In schizophrenia, what is the oral dosage of Haloperidol (serenace)?

Answer 26

1.5mg at night Staged increase to a maximum of 10mg

Question 27

In schizophrenia, what is the oral dosage of periciazine (neulactil)?

Answer 27

10mg at night Staged increase to a maximum of 75mg in staged doses

Question 28

In schizophrenia, what is the depot dosage of Flupentoxol (bentovate)?

Answer 28

10mg, titrated up to 20-40 mg every 2-4 weeks

Question 29

In schizophrenia, what is the depot dosage of Haloperidol (serenace)?

Answer 29

50mg initially, titrated to 50-200mg every 4 weeks

Question 30

In schizophrenia, what is the depot dosage of Paliperidone (invega)?

Answer 30

150mg followed by 100mg one week later (loading dose) 75mg every 4 weeks after Can be titrated between 50-150mg

Question 31

In schizophrenia, what is the depot dosage of Risperidone (risperidal)?

Answer 31

25mg initially Titrate to 25-50mg every 2 weeks +++Drug not released for 3 weeks, needs bridging antipsychotics

Question 32

In schizophrenia, what is the depot dosage of Zuclopenthixol (clopixol)?

Answer 32

100mg initially titrated to 200-400mg every 2-4 weeks

Question 33

In schizophrenia, what is the depot dosage of Olanzapine (pyrex)?

Answer 33

210mg every 2 weeks or 405mg every 4 weeks as a loading dose Then 150mg every 2 weeks or 300mg every 4 weeks thereafter Maximum is 300mg every 2 weeks

Question 34

What is the general MOA of antipsychotics?

Answer 34

D2 receptor blockade (all) D1 blockade (some) Blockade of 5HT2 receptor (some)

Question 35

Indications for antipsychotics

Answer 35

Acute psychosis Chronic psychosis Maintenance therapy for schizophrenia Bipolar

Question 36

Which antipsychotics cause respiratory depression?

Answer 36

Chlorpromazine Clozapine Olanzapine Periciazine

Question 37

What general considerations should be taken into account before starting antipsychotics?

Answer 37

Hyperthyroidism (increases dystonia risk) Temperature regulation (antipsychotics further alter this) Hypotension (drugs can exacerbate this) GI obstruction Urinary obstruction (anticholinergic effects of some drugs can worsen this) Low white cell count or previous blood dyscrasia Diabetes (drugs increase blood glucose) Prolactinoma (increased growth)

Question 38

Which antipsychotics increase the QT interval

Answer 38

Amisulpride Droperidol Haloperidol Ziprasidone

Question 39

Which antipsychotic drugs most commonly cause extrapyramidal side effects?

Answer 39

Haloperidol and trifluoperazine But all can at higher dosages

Question 40

What is the treatment for drug induced acute dystonia?

Answer 40

Benzatropine 1-2mg IM or IV

Question 41

What antipsychotic drug is most associated with skin reactions?

Answer 41

Chlorpromazine - photosensitivity, phototoxicity, hyperpigmentation

Question 42

What are the 5 commonly used TYPICAL antipsychotics?

Answer 42

``` Chlorpromazine (largactil) Periciazine (neulactil) Flupentixol (bentovate) Zulcopenthioxol (clopixol) Haloperidol (serenace) ```

Question 43

What are What are the 11 commonly used ATYPICAL antipsychotics?

Answer 43

``` Amisulpride (solian, sulprix) Aripiprazole (abilify) Brexpiprazole (rexulti) Risperidone (resperidal) Ziprasidone (Ziprox, Zeldox) Lurasidone (ardix, latuda, lupin) Paliperidone (invega) Asenapine (saphris) Clozapine (clopine) Olanzapine (pyrex) Quetiapine (seroquel, quetia, quepine, tevatiapine) ```