Antipsychotic medications Flashcards
Is Amisulpride (solian, solprix) a typical or atypical antipsychotic?
Atypical
Is Aripiprazole (abilify) a typical or atypical antipsychotic?
Atypical
Is Asenapine (Saphris) a typical or atypical antipsychotic?
Atypical
Is Brexpriprazole (rexulti) a typical or atypical antipsychotic?
Atypical
is Chlorpromazine (largactil) a typical or atypical antipsychotic?
Typical
Is Clozapine (Clopine) a typical or atypical antipsychotic?
Atypical
Is Flupentixol (bentovate) a typical or atypical antipsychotic?
Typical
Is Haloperidol (serenace) a typical or atypical antipsychotic?
Typical
Is Lurasidone (Ardix lurasidone, latuda, lurasidone lupin) a typical or atypical antipsychotic?
Atypical
Is Olanzapine (pyrex) a typical or atypical antipsychotic?
Atypical
Is Paliperidone (invega) a typical or atypical antipsychotic?
Atypical
Is periciazine (neulactil) a typical or atypical antipsychotic?
Typical
Is Quetiapine (seroquel, quetia, quepine, tevatiapine) a typical or atypical antipsychotic?
Atypical
Is Risperidone (risperidal) a typical or atypical antipsychotic?
Atypical
Is Ziprasidone (Ziprox, Zeldox) a typical or atypical antipsychotic?
Atypical
Is Zuclopenthixol (clopixol) a typical or atypical antipsychotic?
Typical
In schizophrenia, what is the oral dosage of Amisulpride (solian, solprix)?
100mg at night initially
Increasing to 200mg twice daily
Maximum dose is 1200mg per day
In schizophrenia, what is the oral dosage of Aripiprazole (abilify)?
10mg once daily initially
Increase to 15mg once daily
Maximum dosage is 30mg per day
In schizophrenia, what is the oral dosage of Olanzapine (pyrex)?
5mg at night initially
Increase to 10mg at night
Maximum dose is 30mg per day
In schizophrenia, what is the oral dosage of Paliperidone (invega)?
3mg orally at night
Increase to 6mg at night
Maximum dose is 12mg per day
Adjust dose in renal impairment patients
In schizophrenia, what is the oral dosage of Quetiapine (seroquel, quetia, quepine, tevatiapine)?
50mg twice daily on day 1
100mg twice daily on day 2
Increasing to 200mg twice daily (response usually seen in higher dosages)
Maximum dosage is 800mg per day
In schizophrenia, what is the oral dosage of Risperidone (risperidal)?
0.5-1mg at night initially
Increase to 2mg at night
Maximum dose is 6mg
In schizophrenia, what is the oral dosage of Ziprasidone (Ziprox, Zeldox)?
40mg twice daily with food
Maximum dosage 80mg
In schizophrenia, what is the oral dosage of Asenapine (Saphris)?
5mg sublingually twice per day, before food.
Maximum dosage is 10mg
In schizophrenia, what is the oral dosage of Chlorpromazine (largactil)?
200mg at night initially
Staged increase to maximum of 800mg
In schizophrenia, what is the oral dosage of Haloperidol (serenace)?
1.5mg at night
Staged increase to a maximum of 10mg
In schizophrenia, what is the oral dosage of periciazine (neulactil)?
10mg at night
Staged increase to a maximum of 75mg in staged doses
In schizophrenia, what is the depot dosage of Flupentoxol (bentovate)?
10mg, titrated up to 20-40 mg every 2-4 weeks
In schizophrenia, what is the depot dosage of Haloperidol (serenace)?
50mg initially, titrated to 50-200mg every 4 weeks
In schizophrenia, what is the depot dosage of Paliperidone (invega)?
150mg followed by 100mg one week later (loading dose)
75mg every 4 weeks after
Can be titrated between 50-150mg
In schizophrenia, what is the depot dosage of Risperidone (risperidal)?
25mg initially
Titrate to 25-50mg every 2 weeks
+++Drug not released for 3 weeks, needs bridging antipsychotics
In schizophrenia, what is the depot dosage of Zuclopenthixol (clopixol)?
100mg initially
titrated to 200-400mg every 2-4 weeks
In schizophrenia, what is the depot dosage of Olanzapine (pyrex)?
210mg every 2 weeks or 405mg every 4 weeks as a loading dose
Then 150mg every 2 weeks or 300mg every 4 weeks thereafter
Maximum is 300mg every 2 weeks
What is the general MOA of antipsychotics?
D2 receptor blockade (all)
D1 blockade (some)
Blockade of 5HT2 receptor (some)
Indications for antipsychotics
Acute psychosis
Chronic psychosis
Maintenance therapy for schizophrenia
Bipolar
Which antipsychotics cause respiratory depression?
Chlorpromazine
Clozapine
Olanzapine
Periciazine
What general considerations should be taken into account before starting antipsychotics?
Hyperthyroidism (increases dystonia risk)
Temperature regulation (antipsychotics further alter this)
Hypotension (drugs can exacerbate this)
GI obstruction
Urinary obstruction (anticholinergic effects of some drugs can worsen this)
Low white cell count or previous blood dyscrasia
Diabetes (drugs increase blood glucose)
Prolactinoma (increased growth)
Which antipsychotics increase the QT interval
Amisulpride
Droperidol
Haloperidol
Ziprasidone
Which antipsychotic drugs most commonly cause extrapyramidal side effects?
Haloperidol and trifluoperazine
But all can at higher dosages
What is the treatment for drug induced acute dystonia?
Benzatropine 1-2mg IM or IV
What antipsychotic drug is most associated with skin reactions?
Chlorpromazine - photosensitivity, phototoxicity, hyperpigmentation
What are the 5 commonly used TYPICAL antipsychotics?
Chlorpromazine (largactil) Periciazine (neulactil) Flupentixol (bentovate) Zulcopenthioxol (clopixol) Haloperidol (serenace)
What are What are the 11 commonly used ATYPICAL antipsychotics?
Amisulpride (solian, sulprix) Aripiprazole (abilify) Brexpiprazole (rexulti) Risperidone (resperidal) Ziprasidone (Ziprox, Zeldox) Lurasidone (ardix, latuda, lupin) Paliperidone (invega) Asenapine (saphris) Clozapine (clopine) Olanzapine (pyrex) Quetiapine (seroquel, quetia, quepine, tevatiapine)
