Antipsychotic drugs Flashcards

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1
Q

What are the major EPS symptoms of antipsychotic drugs?

A

1) Dystonia (onset-minutes to hours)
2) Akathisia ( 7 days- weeks)
3) Parkinsonianism (1 week- months)
4) Tardive dyskinesia (months to years-can be irreversible)

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2
Q

Which antipsychotic should be used in cases that are refractory to other drugs?

A

Clozapine (Clozaril)

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3
Q

Which antipsychotic should be used in cases of acute psychosis and what are its major side effects?

A

Olanzapine (Zyprexa) => weight gain, metabolic syndrome, and seizures
-Risperidone (Risperdal) is also a good choice

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4
Q

After what dosage does Risperidone begin to show weight gain and EPS symptoms?

A

8mg

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5
Q

Which antipsychotic is better for patients with Parkinsons?

A

Quetiapine (seroquel) => Does not affect the D2 receptors that are affected in Parkinsons

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6
Q

What is the major side effect of quetiapine?

A

Somnolence and sedation

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7
Q

What antipsychotic can also be used to help with depression?

A

Aripiprazole (Abilify)

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8
Q

Which antipsychotic should be avoided in patients with dementia?

A

Aripiprazole (Abilify)

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9
Q

Which antipsychotic is weight neutral/doesn’t cause weight gain?

A

Ziprasidone (Geodon)

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10
Q

Which class of antipsychotics is associated with weight gain?

A

Atypicals

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11
Q

Which antipsychotic is the least expensive and most often used for acute psychosis?

A

Haloperidol

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12
Q

Which antipsychotic drug is associated with cardiac arrhythmias due to QT prolongation?

A

Ziprasidone (Geodon)

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13
Q

How do neuroleptics (antispychotics) cause hyperprolactinemia?

A

Neuroleptics block the tuberoinfundibular tract which causes increased prolactin leading to: gynecomastia, galactorrhea, and menstrual irregularities

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14
Q

How do neuroleptics (antipsychotics) cause EPS?

A

Neuroleptics block the nigrostriatal tract which leads to the EPS of: tremor, slurred speech, akathisia, dystonia, and tardive dyskinesia.

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15
Q

Which drugs treat EPS?

A
  • Dystonia => benztropine (cogentin), benydryl
  • Parkinsonism/Akinesia => Benztropine, Benadryl (anti-cholinergic agents)
  • Akathisia => beta blockers (propranolol), benzodiazepines
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16
Q

What is neuroleptic malignant syndrome?

A

Often due to high potency antipsychotics:

  • change in mental status
  • autonomic changes (high fever, elevated BP, tachycardia)
  • rigidity
  • sweating
  • elevated CPK
  • leukocytosis
  • metabolic acidosis
  • If these symptoms are seen, stop the offending agent
17
Q

How do high potency and low potency typical antipsychotics differ in side effects?

A
  • High potency => more EPS (bind D2 more tightly)

- Low potency => more anticholinergic/cardiotoxic side effects (tend to block muscarinic receptors more)

18
Q

What is the difference in the mechanism of action of typical vs atypical antipsychotics?

A

Typical => block D2

Atypical => less D2 blockade, more 5HT2a blockade

19
Q

What are some high potency typical anti-psychotics?

A

Fluphenazine, Trifluoperizine, Thiothixene, Haloperidol, Pimozide
- medium-low sedation, high EPS, low anti-cholinergic side effects

20
Q

What are some low potency typical anti-psychotics?

A

Chlorpromazine, Thioridazine

- medium-high sedation, low EPS, high anti-cholinergic/cardiac (QT prolongation) side effects

21
Q

Why are EPS caused?

A

cholinergic/dopamine imbalance

- Decreased dopamine, increased Ach

22
Q

What anti-cholinergic side effects are associated with typical anti-psychotics?

A
  • Dry mouth, blurred vision, constipation, urinary retention, sedation, tachycardia, confusion, delirium, mydriasis, cycloplegia
23
Q

What other side effects ( a part from anti-cholinergic and EPS) are caused by typical anti-psychotics?

A
Neutropenia
Seizures
Cardiac arrhythmias
Hyperthermia
Cataracts
Priapism
24
Q

What is the ranking of metabolic syndrome risk in the atypical anti-psychotics?

A

Clozapine (highest risk) > Olanzapine > Quetiapine, Risperidone > Ziprasidone, Aripiprazole (lowest risk)

25
Q

What is the mechanism of action of Aripiprazole/Abilify?

A

Unique mechanism of action as a D2 partial agonist (at low doses only)

26
Q

How is Aripiprazole different from other atypical antipsychotics in terms of side effect profile?

A

Low EPS, no/minimal QT prolongation or weight gain, low sedation

27
Q

What is Quetiapine/Seroquel most commonly used as?

A

Anti-psychotic with sedation

28
Q

What are the main side effects of Quetiapine/Seroquel?

A
  • Transaminitis

- Orthostatic hypotension

29
Q

Which atypical anti-psychotic functions more like a typical anti-psychotic?

A

Risperidone/Risperdal ( especially >6mg)

30
Q

What atypical is most likely to induce hyperprolactinemia, weight gain, and sedation?

A

Risperidone/Risperdal

31
Q

What atypical anti-psychotic must be taken with food as it increases absorption (nearly 100%)?

A

Ziprasidone/Geodon

32
Q

What are the major side effects of Ziprasidone/Geodon?

A

Vomiting/Nausea

33
Q

Which atypical antipsychotic has its blood levels reduced by smoking and causes transaminitis in a small minority of patients?

A

Olanzapine/Zyprexa

34
Q

Which atypical is the only drug known to reduce suicide risk in patients with schizophrenia?

A

Clozapine

35
Q

What are the major side effects of Clozapine/clozaril?

A
  • Agranulocytosis => monitor weekly for first 6 months (weekly blood tests)
  • Increased risk of seizures
  • Myocarditis
  • Associated with most sedation, weight gain, orthostasis, and transaminitis
  • Metabolic syndrome
36
Q

What atypical is least likely to cause EPS?

A

Clozapine