Antipsychotic drugs Flashcards
What are the major EPS symptoms of antipsychotic drugs?
1) Dystonia (onset-minutes to hours)
2) Akathisia ( 7 days- weeks)
3) Parkinsonianism (1 week- months)
4) Tardive dyskinesia (months to years-can be irreversible)
Which antipsychotic should be used in cases that are refractory to other drugs?
Clozapine (Clozaril)
Which antipsychotic should be used in cases of acute psychosis and what are its major side effects?
Olanzapine (Zyprexa) => weight gain, metabolic syndrome, and seizures
-Risperidone (Risperdal) is also a good choice
After what dosage does Risperidone begin to show weight gain and EPS symptoms?
8mg
Which antipsychotic is better for patients with Parkinsons?
Quetiapine (seroquel) => Does not affect the D2 receptors that are affected in Parkinsons
What is the major side effect of quetiapine?
Somnolence and sedation
What antipsychotic can also be used to help with depression?
Aripiprazole (Abilify)
Which antipsychotic should be avoided in patients with dementia?
Aripiprazole (Abilify)
Which antipsychotic is weight neutral/doesn’t cause weight gain?
Ziprasidone (Geodon)
Which class of antipsychotics is associated with weight gain?
Atypicals
Which antipsychotic is the least expensive and most often used for acute psychosis?
Haloperidol
Which antipsychotic drug is associated with cardiac arrhythmias due to QT prolongation?
Ziprasidone (Geodon)
How do neuroleptics (antispychotics) cause hyperprolactinemia?
Neuroleptics block the tuberoinfundibular tract which causes increased prolactin leading to: gynecomastia, galactorrhea, and menstrual irregularities
How do neuroleptics (antipsychotics) cause EPS?
Neuroleptics block the nigrostriatal tract which leads to the EPS of: tremor, slurred speech, akathisia, dystonia, and tardive dyskinesia.
Which drugs treat EPS?
- Dystonia => benztropine (cogentin), benydryl
- Parkinsonism/Akinesia => Benztropine, Benadryl (anti-cholinergic agents)
- Akathisia => beta blockers (propranolol), benzodiazepines