Antipsychotic Flashcards
1
Q
Risperidone
A
1-2,, 2-6
2
Q
Paliparidone
A
3, 6-12
3
Q
Olanzapine
A
5-10,, 10-20
4
Q
Aripiprazole
A
10-15,, 10-30
5
Q
Quetiapine
A
50,, 300-800
6
Q
Haloperidole
A
2-5
7
Q
Amisulpride
A
50,,, 50-300
400-800
8
Q
Clozapine
A
Almost has 0 effect to dopamine rec
No need to prescribe artane
9
Q
Schizophrenia affect 2 pathway
A
- mesolimbic (hyperactivity) +ve sx
- mesocortical (underactivity) -ve sx
10
Q
Typical eg
A
Chlorpromazine Haloperidol Flupenthixol Perphenazine Sulpiride
11
Q
Antipsychotic SE
A
- D2 rec: EPSE
- M1 rec: bov, dry mouth, tachyp, constipation, urinary retention
- H1 rec: sedarion, insomnia, wt gain
- CV se: torsades de pointes, orthostatic hypotension
- Metabolic syn
- Neuroleptic malignant syn : rare, life threatening, idiosyncratic rxn to neuroleptic meds
12
Q
NMS
A
Due to: high dose, high potency, depot
- fever
- muscle rigidity
- altered mental status
- autonomic instability
(hypertension, tachyp, tachycardia, hyperthermia)
Lab: wcc, ck, myoglobinuria
13
Q
Atypical AP MOA
A
- block dopamine and serotonin rec, but less affinity to dopamine rec (bind transiently at D2)
So less EPSE
