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GI Micro > Antiprotozoans > Flashcards

Antiprotozoans Flashcards

1
Q

trichomonas vaginalis

A

metronidazole and tinidazole

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2
Q

Metronidazole MOA

A

destabilizes DNA.

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3
Q

Giardia lamblia

A

-azoles, and Nitazoxanide in children. Paromomycin

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4
Q

Entamoeba Histolytica

A

paromomycin, or metronidazole followed by paromomycin.

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5
Q

Paromomycin MOA

A

binds 30S ribosome subunit. Acts on bacteria and protozoans

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6
Q

Tinidazole MOA

A

DNA destabilization

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7
Q

Babesia Microti

A

Clindamycin plus quinine or atovaquone plus azithromycin.

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8
Q

Trypanosoma Cruzi

A

Nifurtimox or benznidazole

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9
Q

Trypanosona brucei

A

Pentamidine isethionate (hemolymphatic stage of west african sleeping sickness), Suramin (DOC for East african trypanosomiasis), Melarsoprol (DOC, late disease CNS involvement)

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10
Q

Cryptosporidium parvum

A

Nitazoxanide (DOC in immunocompetant), antiretrovirals in AIDS.

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11
Q

Nitazoxanide MOA

A

unknown - active tizoxanide. Cryptospridium and giardia

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12
Q

Cyclospora cayetanensis

A

TMP-SMX

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13
Q

Microsporidia

A

Albendazole

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14
Q

Leishmaniasis

A

sandflies africa/egypt - sodium stibogluconate - contact the CDC

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15
Q

Pneumocystis Jirovechi/ P carinii (PCP)

A

TMP-SMX, atovaquone, pentamidine

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16
Q

Atovaquone MOA

A

Not for advanced HIV

17
Q

Pentamidine MOA

A

Tx and prevention of pneumonia of PCP - interferes with RNA and DNA , phospholipid, and protein synthesis. - may induce insulin requiring diabetes mellitus.

18
Q

Toxoplasma Gondii

A

pyrimethamine + sulfadiazine (folic acid must always accompany)

19
Q

Pyrimethamine MOA

A

inhibits production of folic acid. Prohylactic and Tx of toxoplasmosis. Must be administered with folic acid

20
Q

Sulfadiazine MOA

A

competetive antagonism of PABA - decrease in folic acid synthesis. Synergistic with pyrimethamine Tx - toxoplasmosis

GI Micro (3 decks)

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